engleski

Serological profiles of hepatitis B and C in kidney transplant donors and recipients

Background: Screening for hepatitis B (HBV) and hepatitis C (HCV) is a requirement in organ transplantation. The information acquired influences organ allocation and further recipient treatment. The goal of this study was to determine the serological profile of kidney graft recipient and donor cohort, as well as the HBV immunity status. Methods: Analysis was conducted using University Hospital Merkur transplant database. HBV and HCV pre- transplantat serology profiles were obtained for kidney transplant donors and recipients from 5/2007 to 6/2016. Results: In the analyzed period there were 452 kidney transplantations (294 male recipients, mean age 49.5 ± 12.5 yrs). 7 (1.5%) recipients were hepatitis B surface antigen (HBsAg) positive. 34.5% of the recipients were HBV non-immune. 37.1% were only HBsAb positive due to vaccination. 10 (2.2%) were only HBcAb positive (Table 1). HBV immunity in the observed period did not change significantly (2007-2011 vs. 2012-2016, p=0, 28) There were 10 (2.2%) HCVAb positive recipients. From the total number of kidney grafts, 40 (8.85%) were HBcAb positive. No grafts were HBsAg or HCVAb positive. Conclusion: HBV immunity in the cohort is low and it has not changed significantly in the observed period. Prevalence of HCVAb in CKD patients undergoing transplantation is low. This analysis shows that greater efforts should be implemented in pre- transplant HBV vaccination.

hepatitis B, hepatitis C, kidney transplant

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