engleski

Anti-obesity effects of anthocyanins in preclinical and clinical studies

The obesity and its related comorbidities represent an emerging global health issue. The natural phytochemicals present in foods, including anthocyanins, might play role in attenuating obesity by producing a decrease in weight and adipose tissue. Nowadays it doesn’t exist a recommended daily allowance although a consumption between 250-400 mg/d, has been identified. This review focused on the current knowledge about anthocyanins’ role in obesity and its related comorbidities reported in animal models and humans. We summarized their target-identification and mechanism of action through several pathways and their final effects on health and well-being. Into consideration ongoing researches, we highlighted following key points: -healthy relationship between anthocyanin supplementation and anti-obesity effects suffers of the same pros and cons evidenced when the beneficial responses to other phytochemical treatments towards different degenerative diseases have been considered ; - the different dosage applied in animal versus clinical studies ; -the complex metabolism and biotransformation to which anthocyanins and phytochemicals are subjected in the intestine and tissues ; -the possibility that different components present in the supplemented mixtures can interact generating antagonistic, synergistic or additive effects difficult to predict, -the difference between prevention and therapy. The evolution of the filed must seriously consider the need to establish new and adequate cellular and animal models which may, in turns, allow the design of more efficient and prevention targeted clinical studies.

obesity ; anthocyanins ; supplementation type ; animal models and humans

Potpora SuRi br. 13.11.1.2.02