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Pregled bibliografske jedinice broj: 876422

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair


Vaz, Bruno; Popović, Marta; ...; Ramadan, Kristijan
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair // Molecular cell, 64 (2016), 4; 704-719 doi:10.1016/j.molcel.2016.09.032 (međunarodna recenzija, članak, znanstveni)


Naslov
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Autori
Vaz, Bruno ; Popović, Marta ; ... ; Ramadan, Kristijan

Izvornik
Molecular cell (1097-2765) 64 (2016), 4; 704-719

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA replication ; DNA-dependent metalloprotease ; DNA-protein crosslink repair ; Ruijs-Aalfs/SPARTAN syndrome ; SPARTAN/DVC1 ; aging ; cancer

Sažetak
The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in cells, either as a consequence of metabolism or exogenous agents, but the mechanism of DPC repair is not completely understood. Here, we characterize SPRTN as a specialized DNA- dependent and DNA replication-coupled metalloprotease for DPC repair. SPRTN cleaves various DNA binding substrates during S-phase progression and thus protects proliferative cells from DPC toxicity. Ruijs-Aalfs syndrome (RJALS) patient cells with monogenic and biallelic mutations in SPRTN are hypersensitive to DPC- inducing agents due to a defect in DNA replication fork progression and the inability to eliminate DPCs. We propose that SPRTN protease represents a specialized DNA replication-coupled DPC repair pathway essential for DNA replication progression and genome stability. Defective SPRTN-dependent clearance of DPCs is the molecular mechanism underlying RJALS, and DPCs are contributing to accelerated aging and cancer.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Citiraj ovu publikaciju

Vaz, Bruno; Popović, Marta; ...; Ramadan, Kristijan
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair // Molecular cell, 64 (2016), 4; 704-719 doi:10.1016/j.molcel.2016.09.032 (međunarodna recenzija, članak, znanstveni)
Vaz, B., Popović, M., ... & Ramadan, K. (2016) Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair. Molecular cell, 64 (4), 704-719 doi:10.1016/j.molcel.2016.09.032.
@article{article, year = {2016}, pages = {704-719}, DOI = {10.1016/j.molcel.2016.09.032}, keywords = {DNA replication, DNA-dependent metalloprotease, DNA-protein crosslink repair, Ruijs-Aalfs/SPARTAN syndrome, SPARTAN/DVC1, aging, cancer}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2016.09.032}, volume = {64}, number = {4}, issn = {1097-2765}, title = {Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair}, keyword = {DNA replication, DNA-dependent metalloprotease, DNA-protein crosslink repair, Ruijs-Aalfs/SPARTAN syndrome, SPARTAN/DVC1, aging, cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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