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Pregled bibliografske jedinice broj: 876411

Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives


Lapić, Jasmina; Toma, Mateja; Novaković, Anja; Filipović, Alma; Šakić, Davor; Vrček, Valerije; Djaković, Senka
Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives // 25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem / Ana Šantić, Marijana Đaković (ur.).
Zagreb: HKD/CCS, 2017. str. 139-139 (poster, domaća recenzija, sažetak, znanstveni)


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Naslov
Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives

Autori
Lapić, Jasmina ; Toma, Mateja ; Novaković, Anja ; Filipović, Alma ; Šakić, Davor ; Vrček, Valerije ; Djaković, Senka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem / Ana Šantić, Marijana Đaković - Zagreb : HKD/CCS, 2017, 139-139

Skup
25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem

Mjesto i datum
Poreč, Hrvatska, 19-22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
organometallic chemistry, electrochemistry, bioactive compounds, synthesis, reaction mechanism, DFT

Sažetak
Pyrimidines and purines substituted by ferrocenyl moiety present interesting organometallic conjugates as their structures incorporate both biologically and electrochemically active components. The first syntheses of ferrocenyl-nucleobases were reported by Chen in 1980 [1, 2]. In our previous study were prepared ferrocenoylated N1-pyrimidine nucleobases (uracil, thymine and 5-fluorouracil). The synthetic procedure to obtain exclusively the N1-regioisomer does not require any protection of the N3-position in the nucleobase. The nucleophilic addition of pyrimidine bases to the carbonyl group of FcCOCl proceeds by a concerted SN2-like mechanism with the absence of the generally assumed tetrahedral intermediate. [3] This report will refer to the preparation procedure of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives. Regioselectivity of these reactions have been analyzed in details by NMR spectroscopy and quantum chemical calculations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-1137 - Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza (Valerije Vrček, HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb

Citiraj ovu publikaciju

Lapić, Jasmina; Toma, Mateja; Novaković, Anja; Filipović, Alma; Šakić, Davor; Vrček, Valerije; Djaković, Senka
Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives // 25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem / Ana Šantić, Marijana Đaković (ur.).
Zagreb: HKD/CCS, 2017. str. 139-139 (poster, domaća recenzija, sažetak, znanstveni)
Lapić, J., Toma, M., Novaković, A., Filipović, A., Šakić, D., Vrček, V. & Djaković, S. (2017) Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives. U: Ana Šantić, M. (ur.)25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem.
@article{article, editor = {Ana \v{S}anti\'{c}, M.}, year = {2017}, pages = {139-139}, keywords = {organometallic chemistry, electrochemistry, bioactive compounds, synthesis, reaction mechanism, DFT}, title = {Synthesis and characterization of homo- and heteroannularly substituted ferrocenoyl-cytosine derivatives}, keyword = {organometallic chemistry, electrochemistry, bioactive compounds, synthesis, reaction mechanism, DFT}, publisher = {HKD/CCS}, publisherplace = {Pore\v{c}, Hrvatska} }




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