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Electrochemistry of Redox-active Mn Porphyrin- based SOD Mimic MnTnBuOE-2-PyP5+ - Study of Redox Species Involved in ROS/RNS Scavenging

Manganese ortho tetrakis(N-n- butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE- 2-PyP5+, is a third-generation redox-active compound currently undergoing preclinical exploration. This work is intended to complement the already extensive research of its chemical and biological properties by a simple electrochemical study. The thermodynamic parameters related to the Mn(IV) porphyrin species of MnTnBuOE-2-PyP5+ determined in this work support its observed reactivity as an efficient scavenger of peroxynitrite. The corresponding driving forces for the possible single-electron or two-electron reductions of ONOO- have been estimated as well.

metalloporphyrins ; oxidative stress ; superoxide ; peroxynitrite ; cyclic voltammetry

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