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Pregled bibliografske jedinice broj: 875361

Determinants of retinal microvascular features and their relationships in two European populations


Kirin, Mirna; Nagy, R.; MacGillivray, T.J.; Polašek, Ozren; Hayward, C.; Campbell. H.; Wild, S.; Wright, A.F.; Wilson, J.F.; Vitart, V.
Determinants of retinal microvascular features and their relationships in two European populations // Journal of hypertension, 35 (2017), 8; 1646-1659 doi:10.1097/HJH.0000000000001408 (međunarodna recenzija, članak, znanstveni)


Naslov
Determinants of retinal microvascular features and their relationships in two European populations

Autori
Kirin, Mirna ; Nagy, R. ; MacGillivray, T.J. ; Polašek, Ozren ; Hayward, C. ; Campbell. H. ; Wild, S. ; Wright, A.F. ; Wilson, J.F. ; Vitart, V.

Izvornik
Journal of hypertension (0263-6352) 35 (2017), 8; 1646-1659

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Retinal, photo, gene

Sažetak
Objectives were zo examine factors influencing retinal vasculature in two environmentally contrasted, cross-sectional studies of adult participants of European descent and to estimate the extent and specificity of genetic contributions to each retinal vasculature feature. Retinal images from 1088 participants in the Orkney Complex Disease Study and 387 in the Croatia-Korčula study, taken using the same nonmydriatic camera system and graded by the same person, were evaluated. Using general linear models, we estimated the influence of an extensive range of systemic risk factors, calculated retinal traits heritabilities and genetic correlations. Systemic covariates explained little (<4%) of the variation in vessel tortuosity, substantially more (>10%, up to 31.7%) of the variation in vessel width and monofractal dimension. Suggestive not well trodden associations of biological interest included that of urate, tissue plasminogen activator and cardiac PR interval with arteriolar narrowing, that of carotid intima- media thickness with less-tortuous arterioles and of cardiac QT interval with more tortuous venules. The genetic underpinning of tortuosity is largely distinct from that of the other retinal vascular features, whereas that of fractal dimension and vessel width greatly overlaps. The previously recognized influence of ocular axial length on vessel widths was high and can be expected to lead to artefactual genetic associations [genetic correlation with central retinal arteriolar equivalent: -0.53 (standard error 0.11)]. The significant genetic correlation between SBP and central retinal arteriolar equivalent, -0.53 (standard error 0.22) (after adjusting for age, sex and axial length of the eye), augurs more favourably for the discovery of genetic variants relevant to vascular physiology.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne tehničke znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-IP-2013-11-8875 - Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Autor s matičnim brojem:
Ozren Polašek, (271725)

Citiraj ovu publikaciju

Kirin, Mirna; Nagy, R.; MacGillivray, T.J.; Polašek, Ozren; Hayward, C.; Campbell. H.; Wild, S.; Wright, A.F.; Wilson, J.F.; Vitart, V.
Determinants of retinal microvascular features and their relationships in two European populations // Journal of hypertension, 35 (2017), 8; 1646-1659 doi:10.1097/HJH.0000000000001408 (međunarodna recenzija, članak, znanstveni)
Kirin, M., Nagy, R., MacGillivray, T., Polašek, O., Hayward, C., Campbell. H., Wild, S., Wright, A., Wilson, J. & Vitart, V. (2017) Determinants of retinal microvascular features and their relationships in two European populations. Journal of hypertension, 35 (8), 1646-1659 doi:10.1097/HJH.0000000000001408.
@article{article, year = {2017}, pages = {1646-1659}, DOI = {10.1097/HJH.0000000000001408}, keywords = {retinal, photo, gene}, journal = {Journal of hypertension}, doi = {10.1097/HJH.0000000000001408}, volume = {35}, number = {8}, issn = {0263-6352}, title = {Determinants of retinal microvascular features and their relationships in two European populations}, keyword = {retinal, photo, gene} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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