engleski

Synthesis of novel trisubstituted imidazole derivatives as potential antioxidant and antibacterial agents

Some wellknown components of human organism like, histidine, Vit-B12, a component of DNA base structure and purines, histamine and biotin have imidazole nucleus in their core structure. It is also incorporated in many synthetic drug molecules. Cimetidine, Azomycin, and Metronidazole are the known examples of it. Imidazole core structure containing drugs have a broaden scope in remedying various dispositions in clinical medicine. Imidazole was found to exhibit antibacterial, anticancer, antitubercular, antifungal, antianalgesic, anti-HIV, antioxidant, antidepressant and antihypertensive activity. In order to obtain novel potential antioxidant and antibacterial agents, we performed a synthesis of novel series of tri-substituted imidazole derivatives according to well-known Radziszewski reaction. Desired molecules (3) were obtained from the reaction of benzil (1) , ammonium acetate and 3-(4-fluorophenyl)-5-(substituted phenyl)-4, 5- dihydro-1H-pyrazole-1-carbaldehyde (2). All compounds were characterized by mass, IR and NMR spectroscopy and screened for their antioxidant and antibacterial activity, using DPPH method and broth dilution method. Most of them found to be active as antibacterials and antioxidants with moderate to excellent activity.

imidazole ; antioxidant ; antibacterial

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