engleski

Copper(II) complexes with benzhydrazone-related ligands : synthesis, structural studies and cytotoxicity assay

The dinuclear copper(II) complexes [Cu2(LH)2] (1), [Cu2(L3OMe)2] (2), [Cu2(L4OMe)2] (3) as well as the tetranuclear complex [Cu4(L3OMe)4]∙4MeOH∙2H2O (2a•4MeOH•2H2O), (where LH = 2-oxybenzaldehyde benzhydrazonato, L3OMe = 3-methoxy-2- oxybenzaldehyde benzhydrazonato or L4OMe = 4- methoxy-2-oxybenzaldehyde benzhydrazonato) were synthesized by reacting copper(II) acetate with the corresponding aroylhydrazone. Reactions in the presence of N-donor ligands D (pyridine, 4, 4'- bipyridine or 1, 10-phenanthroline) afforded complexes with different nuclearities and Cu:L:D ratios. They can be classified as dinuclear, [Cu2(LH)2(py)2] (1py), [Cu2(L3OMe)2(py)2]∙3H2O (2py∙3H2O), [Cu2(L4OMe)2(py)2] (3py), [{; ; ; ; ; Cu(LH)}; ; ; ; ; 2(bpy)] (1bpy), [{; ; ; ; ; Cu(L3OMe)}; ; ; ; ; 2(bpy)] (2bpy), and [{; ; ; ; ; Cu(L4OMe)}; ; ; ; ; 2(bpy)] (3bpy), mononuclear [Cu(LH)(phen)] (1phen), [Cu(L3OMe) (phen)] (2phen) and [Cu(L4OMe)(phen)] (3phen), and polynuclear [{; ; ; ; ; Cu(LH)}; ; ; ; ; 2(bpy)]n∙2nMeOH (1bpy*∙2MeOH) complexes. Conversion of complexes 1py−3py to complexes 1−3 proceeded via solid state reactions. Crystal and molecular structures of 2a•4MeOH•2H2O, 2py•3H2O, 3py, 1bpy*•2MeOH, 2bpy, 1phen and 3phen were determined by the single crystal X-ray diffraction method. All complexes were characterized by means of elemental and thermogravimetric analysis, FT-IR spectroscopy and the powder X-ray diffraction method. In vitro cytotoxicity of benzhydrazone-related ligands and their copper(II) complexes against THP-1 and HepG2 cells demonstrated that the complexes are significantly more cytotoxic than the corresponding ligands.

Copper(II) complexes ; Benzhydrazone ; Cytotoxicity

nije evidentirano