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Pregled bibliografske jedinice broj: 873179

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error


Fan, Q.; ...; Polašek, Ozren; ...; Rudan, Igor; Vatavuk, Zoran; ...; ...; Mäkelä, K.M.
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error // Nature Communications (2017) (znanstveni, prihvaćen)


Naslov
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Autori
Fan, Q. ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; Vatavuk, Zoran ; ... ; ... ; Mäkelä, K.M.

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Nature Communications (2017)

Status rada
Prihvaćen

Ključne riječi
Refractive error, gene

Sažetak
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40, 036 adults from 25 studies of European ancestry and 10, 315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
Consortium for Refractive Error and Myopia.



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE