Genetic variants linked to education predict longevity (CROSBI ID 238687)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Marioni, R.E. ; ... ; Polašek, Ozren ; ... ; Kolčić, Ivana ; ... ; Dearry, Ian
engleski
Genetic variants linked to education predict longevity
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17, 000 ; UK Biobank, n = ∼115, 000 ; and the Estonian Biobank, n = ∼6, 000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79, 702) and ∼2.4% lower risk for fathers (total ndeaths = 97, 630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
longevity, education, gene
Social Science Genetic Association Consortium.
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
113 (47)
2016.
13366-13371
objavljeno
0027-8424
10.1073/pnas.1605334113
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita