Minimal artificial enzymes: Application of "backdoor induction" in asymmetric catalysis (CROSBI ID 647239)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kirin, Srećko I.
engleski
Minimal artificial enzymes: Application of "backdoor induction" in asymmetric catalysis
The development of new small-molecule transition metal catalysts for asymmetric reactions is often fuelled by imitating metalloenzyme active sites. Nevertheless, small-molecule transition metal catalysts are still easily outperformed by metalloenzymes in terms of both selectivity and reaction rates. It is obvious that mimicking the active site alone is not sufficient to replicate metalloenzyme activity. Therefore we design artificial metalloenzymes that contain not only an enzyme active site mimic but also a minimal functional outercoordination sphere. A major feature of these minimal artificial enzymes is "backdoor induction" of chirality via hydrogen bonding and other non-covalent interactions between distant chiral amide substituents, e. g. amino acids, diamines or dicarboxylic acids. Additional favorable properties are cheap synthesis by standard chemical methods as well as possible application to a broad range of substrates. In this presentation, several selected approaches for the development of new catalytic systems will be discussed [1]. Particular emphasis will be focused on supramolecular systems comprising well defined artificial secondary structures [2], with the potential to transmit chiral information from the outer-coordination sphere to the prochiral catalytically active metal centre.
artificial metalloenzymes
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Podaci o prilogu
35-35.
2017.
objavljeno
Podaci o matičnoj publikaciji
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog : knjiga sažetaka = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog” : Book of Abstracts
Šantić, Ana ; Đaković, Marijana
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo
978-953-552327-7
Podaci o skupu
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog”
pozvano predavanje
12.04.2017-22.04.2017
Poreč, Hrvatska