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Pregled bibliografske jedinice broj: 873090

Minimal artificial enzymes: Application of "backdoor induction" in asymmetric catalysis


Kirin, Srećko I.
Minimal artificial enzymes: Application of "backdoor induction" in asymmetric catalysis // Book of abstracts
Poreč, Hrvatska, 2017. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Minimal artificial enzymes: Application of "backdoor induction" in asymmetric catalysis

Autori
Kirin, Srećko I.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / - , 2017

Skup
25. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Poreč, Hrvatska, 19.-22. 04. 2017.

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Artificial metalloenzymes,

Sažetak
The development of new small-molecule transition metal catalysts for asymmetric reactions is often fuelled by imitating metalloenzyme active sites. Nevertheless, small-molecule transition metal catalysts are still easily outperformed by metalloenzymes in terms of both selectivity and reaction rates. It is obvious that mimicking the active site alone is not sufficient to replicate metalloenzyme activity. Therefore we design artificial metalloenzymes that contain not only an enzyme active site mimic but also a minimal functional outercoordination sphere. A major feature of these minimal artificial enzymes is "backdoor induction" of chirality via hydrogen bonding and other non-covalent interactions between distant chiral amide substituents, e. g. amino acids, diamines or dicarboxylic acids. Additional favorable properties are cheap synthesis by standard chemical methods as well as possible application to a broad range of substrates. In this presentation, several selected approaches for the development of new catalytic systems will be discussed [1]. Particular emphasis will be focused on supramolecular systems comprising well defined artificial secondary structures [2], with the potential to transmit chiral information from the outer-coordination sphere to the prochiral catalytically active metal centre.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-1461 - Minimalni umjetni enzimi: Proširenje primjene posredne indukcije na nove supstrate i nove asimetrične reakcije (Srećko Kirin, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Srećko Kirin, (192540)