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Brain-derived neurotrophic factor plasma levels: relationship to cognitive and non- cognitive symptoms of dementia


Nikolac Perkovic, Matea; Borovecki, Fran; Filipcic, Igor; Pivac, Nela
Brain-derived neurotrophic factor plasma levels: relationship to cognitive and non- cognitive symptoms of dementia // 10th FENS Forum of Neuroscience
Kopenhagen, Danska, 2016. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Brain-derived neurotrophic factor plasma levels: relationship to cognitive and non- cognitive symptoms of dementia

Autori
Nikolac Perkovic, Matea ; Borovecki, Fran ; Filipcic, Igor ; Pivac, Nela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
10th FENS Forum of Neuroscience

Mjesto i datum
Kopenhagen, Danska, 2.-7.07.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BDNF, cognition, dementia, plasma

Sažetak
Brain derived neurotrophic factor (BDNF) is a crucial mediator of neuronal plasticity and the most widely distributed member of neurotrophin family. The aim of this study was to provide a better insight into the role of BDNF in the development of cognitive, behavioral and psychological symptoms of dementia (BPSD). The study included 207 patients with Alzheimer’s disease (AD), 59 patients with mild cognitive impairment (MCI) and 52 patients with non-AD types of dementia. Cognitive impairment was evaluated using the Mini-Mental Status Examination (MMSE), while the frequency of BPSD was evaluated with the Neuropsychiatric Inventory. Plasma BDNF levels were measured with enzyme-linked immunosorbent assay, according to the procedures supplied by the manufacturer (R&D Systems GmbH). Our results revealed increased BDNF plasma concentration in patients with AD compared to subjects diagnosed with MCI or other types of dementia (H=14.22 ; df=4 ; p=0.007). When patients with AD were subdivided according to the MMSE scores into patients with mild, moderate, and severe cognitive impairment, a significant (H=9.45 ; df=4 ; p=0.050) association was detected between BDNF plasma levels and cognitive decline. The results also corroborated the role of BDNF in the development of BPSD, as a positive correlation between BDNF plasma levels and symptoms of anxiety (r=0.22 ; p=0.002), sleep disorders and nocturnal restlessness (r=0.19 ; p=0.025), appetite distress and eating disorders (r=0.18 ; p=0.039) was found. These data provided further insight in the important role of BDNF in dementia, by demonstrating a significant association between lower plasma BDNF levels and more severe cognitive and non-cognitive symptoms of dementia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb