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Pregled bibliografske jedinice broj: 872362

Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles


Cindrić, Maja; Sović, Irena; Martin-Kleiner, Irena; Kralj, Marijeta; Mašek, Tomislav; Hranjec, Marijana; Starčević, Kristina
Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles // Medicinal chemistry research, 26 (2017), 9; 2024-2037 doi:10.1007/s00044-017-1912-z (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles

Autori
Cindrić, Maja ; Sović, Irena ; Martin-Kleiner, Irena ; Kralj, Marijeta ; Mašek, Tomislav ; Hranjec, Marijana ; Starčević, Kristina

Izvornik
Medicinal chemistry research (1054-2523) 26 (2017), 9; 2024-2037

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Amidines, benzamides, benzimidazoles, methoxy groups, antioxidative activity, antiproliferative activity

Sažetak
Within this manuscript the synthesis and potential antioxidative and antiproliferative activity of novel methoxy amidino substituted bezamides 6-17 and benzimidazoles 23-28 and 32-35 is presented. Their antioxidative potency has been evaluated by in vitro spectrophotometric assays and preliminary structure-activity relationships among the synthesized compounds are discussed. The compound 28 bearing three methoxy groups on a phenyl ring and imidazolinyl amidine groupe on benzimidazole nucleous directly attached to the phenyl ring exhibited the most prominent reducing activity as well as free-radical scavenging activity. Furthermore all novel compounds were tested against three human cell lines: HCT 116 (colon carcinoma), H 460 (lung carcinoma) and MCF-7 (breast carcinoma). The most prominent antiproliferative effect in the single-digit micromolar range was observed for compound 33 on MCF-7 (IC50 = 9 µM) cell line, comparable to the standard etoposide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (Silvana Raić-Malić, )
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (Marijeta Kralj, )

Ustanove
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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