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Pregled bibliografske jedinice broj: 872362

Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles


Cindrić, Maja; Sović, Irena; Martin-Kleiner, Irena; Kralj, Marijeta; Mašek, Tomislav; Hranjec, Marijana; Starčević, Kristina
Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles // Medicinal chemistry research, 26 (2017), 9; 2024-2037 doi:10.1007/s00044-017-1912-z (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 872362 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles

Autori
Cindrić, Maja ; Sović, Irena ; Martin-Kleiner, Irena ; Kralj, Marijeta ; Mašek, Tomislav ; Hranjec, Marijana ; Starčević, Kristina

Izvornik
Medicinal chemistry research (1054-2523) 26 (2017), 9; 2024-2037

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
amidines, benzamides, benzimidazoles, methoxy groups, antioxidative activity, antiproliferative activity

Sažetak
Within this manuscript the synthesis and potential antioxidative and antiproliferative activity of novel methoxy amidino substituted bezamides 6-17 and benzimidazoles 23-28 and 32-35 is presented. Their antioxidative potency has been evaluated by in vitro spectrophotometric assays and preliminary structure-activity relationships among the synthesized compounds are discussed. The compound 28 bearing three methoxy groups on a phenyl ring and imidazolinyl amidine groupe on benzimidazole nucleous directly attached to the phenyl ring exhibited the most prominent reducing activity as well as free-radical scavenging activity. Furthermore all novel compounds were tested against three human cell lines: HCT 116 (colon carcinoma), H 460 (lung carcinoma) and MCF-7 (breast carcinoma). The most prominent antiproliferative effect in the single-digit micromolar range was observed for compound 33 on MCF-7 (IC50 = 9 µM) cell line, comparable to the standard etoposide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (MultiCaST) (Kralj, Marijeta, HRZZ)
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (SCIENcENTRY) (Raić-Malić, Silvana, HRZZ)

Ustanove
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Citiraj ovu publikaciju

Cindrić, Maja; Sović, Irena; Martin-Kleiner, Irena; Kralj, Marijeta; Mašek, Tomislav; Hranjec, Marijana; Starčević, Kristina
Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles // Medicinal chemistry research, 26 (2017), 9; 2024-2037 doi:10.1007/s00044-017-1912-z (međunarodna recenzija, članak, znanstveni)
Cindrić, M., Sović, I., Martin-Kleiner, I., Kralj, M., Mašek, T., Hranjec, M. & Starčević, K. (2017) Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles. Medicinal chemistry research, 26 (9), 2024-2037 doi:10.1007/s00044-017-1912-z.
@article{article, year = {2017}, pages = {2024-2037}, DOI = {10.1007/s00044-017-1912-z}, keywords = {amidines, benzamides, benzimidazoles, methoxy groups, antioxidative activity, antiproliferative activity}, journal = {Medicinal chemistry research}, doi = {10.1007/s00044-017-1912-z}, volume = {26}, number = {9}, issn = {1054-2523}, title = {Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles}, keyword = {amidines, benzamides, benzimidazoles, methoxy groups, antioxidative activity, antiproliferative activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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