Synthesis of marine alkaloids leucettamines B and C by beta-lactam ring rearrangement (CROSBI ID 238519)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dražić, Tonko ; Molčanov, Krešimir ; Jurin, Mladenka ; Roje, Marin
engleski
Synthesis of marine alkaloids leucettamines B and C by beta-lactam ring rearrangement
A new method for the synthesis of marine alkaloids leucettamines B and C from Leucetta sp. sponges is described. The key step is the base-promoted rearrangement of β-lactam into imidazolone ring. Leucettamines B and C as well as their N-benzoyl derivatives were obtained in high yields. Single-crystal structures of both leucettamines B and C were determined by X-ray diffraction confirming Z-configuration of double bond at 4-position of imidazolone.
2-aminoimidazolone, β-lactam, marine alkaloids, transformation
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano