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Pregled bibliografske jedinice broj: 872135

Synthesis of novel 2-arylbenzothiazole derivatives and biological evaluation of antioxidant, antibacterial and antitumor activity


Racane, Livio; Tralić-Kulenović, Vesna; Fajdetić, Glorija; Klobučar, Marko; Kraljević Pavelić, Sandra; Perić, Mihaela; Čipčić Paljetak, Hana; Verbanac, Donatella; Starčević, Kristina
Synthesis of novel 2-arylbenzothiazole derivatives and biological evaluation of antioxidant, antibacterial and antitumor activity // 25th Croatian meeting of chemists and chemical engineers - Book of Abstracts / Šantić, A ; Đaković, M. (ur.).
Zagreb: HKD/HDKI, 2017. str. 203-203 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Synthesis of novel 2-arylbenzothiazole derivatives and biological evaluation of antioxidant, antibacterial and antitumor activity

Autori
Racane, Livio ; Tralić-Kulenović, Vesna ; Fajdetić, Glorija ; Klobučar, Marko ; Kraljević Pavelić, Sandra ; Perić, Mihaela ; Čipčić Paljetak, Hana ; Verbanac, Donatella ; Starčević, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25th Croatian meeting of chemists and chemical engineers - Book of Abstracts / Šantić, A ; Đaković, M. - Zagreb : HKD/HDKI, 2017, 203-203

Skup
25th Croatian meeting of chemists and chemical engineers

Mjesto i datum
Poreč, Hrvatska, 19.-22.04.2017.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
2-arylbenzothiazole, biological evaluation

Sažetak
Studies of benzothiazole derivatives became a rapidly developing and increasingly active field due to their interesting pharmacological properties. Benzothiazole analogues offer a high degree of structural diversity that is useful in search of new therapeutic agents [1]. In connection with our previous studies focused on synthesis and antitumor activity of 2- arylbenzothiazole derivatives [2-4] we now put our attention on the synthesis of a series of novel 2-hydroxyphenyl- and 2- methoxyphenylbenzothiazole compounds (Figure 1). Different substituents at 6-position of the benzothiazole skeleton were introduced through condensation reactions involving 5-substituted- 2-aminothiphenols and the corresponding benzaldehydes. Antiproliferative effects of compounds 1-12 were evaluated on a panel of tumor cell lines in vitro and normal human fibroblasts. Antibacterial properties were determined against two G+ and two G- bacterial strains. In addition, in vitro antioxidant potencies were measured by use of DPPH, FRAP and ABTS tests. Preliminary structure-activity relationships for synthesized compounds are presented herein.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (Silvana Raić-Malić, )

Ustanove
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju