engleski

What affects the outcome of severe preeclampsia?

Preeclampsia is a severe multi-system pregnancy related disorder which is associated with multiple maternal and fetal adverse outcome including fetal and maternal mortality. The aim of this study is to investigate the clinical difference between early and late onset preeclampsia and their impact to perinatal outcome and to detect possible antenatal parameter that can predict adverse fetal and maternal outcome. A retrospective cohort study of 308 singleton pregnancies complicated with severe preeclampsia over a 8-year period in our tertiary level centre. Clinical differences and perinatal outcome between early (<34 weeks, n=147) and late-onset (≥34 weeks, n=161) preeclampsia were analyzed. Possible antenatal risk factors with the influence to adverse perinatal outcome in severe preeclampsia were also evaluated. Clinical simptoms and perinatal outcome were significantly unfavorable in early-onset preeclampsia. Adverse perinatal outcome in the early onset group was complicated with 10 (6.08%) intrauterine fetal deaths and 4 (2.37%) neonatal deaths. Primiparity seems to be the significant antenatal risk factor for appearance of early onset of the disease (p<0.001, OR 2.39, 95% CI 1.48-3.86) and for the 1 st minute Apgar score <7 (p=0.036, OR 1.68, 95% CI 1.04-2.74). Patients with severe preeclampsia are a high- risk obstetric patients because of unpredictability, varying clinical presentation and potential adverse outcomes of the disease. Pregnant women with early appearance of the disease had severe clinical presentation and more often unfavorable perinatal outcome.

preeclampsia ; pregnancy ; outcome

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