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Pregled bibliografske jedinice broj: 870727

Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C- peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial


Horvatiček, Marina; Đelmiš, Josip; Ivanišević, Marina; Orešković, Slavko; Herman, Mislav
Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C- peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial // European journal of clinical nutrition, 71 (2017), 8; 968-972 doi:10.1038/ejcn.2017.46 (međunarodna recenzija, članak, znanstveni)


Naslov
Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C- peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial

Autori
Horvatiček, Marina ; Đelmiš, Josip ; Ivanišević, Marina ; Orešković, Slavko ; Herman, Mislav

Izvornik
European journal of clinical nutrition (0954-3007) 71 (2017), 8; 968-972

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
C-peptide ; type-1 diabetes ; pregnancy ; n-3 polyunsaturated fatty acids ; supplementation

Sažetak
Type-1 diabetes mellitus (T1DM) is caused by autoimmune insulitis. There are evidences that pregnancy and n-3 fatty acids exhibit suppressive effect on human inflammatory system. Ninety pregnant women with T1DM were included in the prospective randomized placebo controlled clinical trial. Forty-seven of them were put on standard diabetic diet enriched with EPA and DHA twice a day (EPA 120 mg and DHA 616 mg ; Study group) and 43 pregnant diabetic women were on standard diabetic diet with placebo (Control group). Duration of T1DM in all participants was between 5 to 30 years. Blood samples were analyzed from all pregnant women for fasting C-peptide (FC- peptide), fasting plasma glucose (FPG) and HbA1c in each trimester throughout pregnancy and after delivery. Umbilical vein blood was analyzed for fetal C-peptide level, glucose concentration and insulin resistance. In the Study group FC-peptide concentration raised from 59.6±103.9 pmol/l in first trimester, to 67.7±101.3 pmol/l in the second trimester and to 95.1±152.7 pmol/l in the third trimester. Comparing the FC-peptide values during first and third trimester a statistically significant increase in third trimester was found (P<0.001). In the Control group FC-peptide concentration ranged from 41.7±91.6 pmol/l in the first trimester to 41.2±70.9 mmol/l in the second trimester while in the third trimester it reached 52.4±95.3 pmol/l. Comparing the FC-peptide values during first and third trimester the statistical difference was not significant. Combining of LC n-3 PUFAs and pregnancy yields immunological tolerance and stimulates the production of endogenous insulin in women with T1DM.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Horvatiček, Marina; Đelmiš, Josip; Ivanišević, Marina; Orešković, Slavko; Herman, Mislav
Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C- peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial // European journal of clinical nutrition, 71 (2017), 8; 968-972 doi:10.1038/ejcn.2017.46 (međunarodna recenzija, članak, znanstveni)
Horvatiček, M., Đelmiš, J., Ivanišević, M., Orešković, S. & Herman, M. (2017) Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C- peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial. European journal of clinical nutrition, 71 (8), 968-972 doi:10.1038/ejcn.2017.46.
@article{article, year = {2017}, pages = {968-972}, DOI = {10.1038/ejcn.2017.46}, keywords = {C-peptide, type-1 diabetes, pregnancy, n-3 polyunsaturated fatty acids, supplementation}, journal = {European journal of clinical nutrition}, doi = {10.1038/ejcn.2017.46}, volume = {71}, number = {8}, issn = {0954-3007}, title = {Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C- peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial}, keyword = {C-peptide, type-1 diabetes, pregnancy, n-3 polyunsaturated fatty acids, supplementation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Science Citation Index


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