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Pregled bibliografske jedinice broj: 870079

Non-random inversion landscapes in prokaryotic genomes are shaped by heterogeneous selection pressures


Repar, Jelena; Warnecke, Tobias
Non-random inversion landscapes in prokaryotic genomes are shaped by heterogeneous selection pressures // Molecular biology and evolution, 34 (2017), 8; 1902-1911 doi:10.1093/molbev/msx127 (međunarodna recenzija, članak, znanstveni)


Naslov
Non-random inversion landscapes in prokaryotic genomes are shaped by heterogeneous selection pressures

Autori
Repar, Jelena ; Warnecke, Tobias

Izvornik
Molecular biology and evolution (0737-4038) 34 (2017), 8; 1902-1911

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Symmetric inversions, oriC, genome rearrangements

Sažetak
Inversions are a major contributor to structural genome evolution in prokaryotes. Here, using a novel alignment-based method, we systematically compare 1651 bacterial and 98 archaeal genomes to show that inversion landscapes are frequently biased towards (symmetric) inversions around the origin- terminus axis. However, symmetric inversion bias is not a universal feature of prokaryotic genome evolution but varies considerably across clades. At the extremes, inversion landscapes in Bacillus-Clostridium and Actinobacteria are dominated by symmetric inversions, while there is little or no systematic bias favouring symmetric rearrangements in archaea with a single origin of replication. Within clades, we find strong but clade-specific relationships between symmetric inversion bias and different features of adaptive genome architecture, including the distance of essential genes to the origin of replication and the preferential localization of genes on the leading strand. We suggest that heterogeneous selection pressures have converged to produce similar patterns of structural genome evolution across prokaryotes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Računarstvo



POVEZANOST RADA


Autor s matičnim brojem:
Jelena Repar, (290662)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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