Biomarkers of oxidative and nitro-oxidative stress: conventional and novel approaches (CROSBI ID 238190)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Čipak Gašparović, Ana ; Žarković, Neven ; Žarković, Kamelija ; Semen, Khrystyna ; Kaminskyy, Danylo ; Yelisyeyeva, Olha ; Bottari, Serge P.
engleski
Biomarkers of oxidative and nitro-oxidative stress: conventional and novel approaches
The concept of oxidative stress (OS) that connects altered redox biology with various diseases was introduced 30 years ago and has generated intensive research over the past two decades. Whereas it is now commonly accepted that macromolecule oxidation in response to ROS is associated with a variety of pathologies, the emergence of NOas a key regulator of redox signalling has led to the discovery of the pathophysiological significance of reactive nitrogen species (RNS). RNS can elicit various modifications of macromolecules and lead to nitrative or nitro- OS. In order to investigate oxidative and nitro-OS in human and in live animal models, circulating biomarker assays have been developed. This article provides an overview of key biomarkers used to assess lipid peroxidation and NO/NO2 signalling, thereby stressing the necessity to analyse several OS biomarkers in relation to the overall (aerobic) metabolism and health condition of patients. In addition, the potential interest of heart rate variability as the non-invasive integrative biomarker of OS is discussed.
HNE ; ALE ; S-nitrosation ; LPO ; redox signalling ; nitro-oxidative stress
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
174 (12)
2017.
1771-1783
objavljeno
0007-1188
1476-5381
10.1111/bph.13673
Povezanost rada
Temeljne medicinske znanosti