1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro (CROSBI ID 238074)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Knežević Teofilović, Natalija ; Bihi, Majjoub ; Radić Stojković, Marijana ; Tumir, Lidija ; Ester, Katja ; Kralj, Marijeta ; Majhen, Dragomira ; Oršolić, Nada ; Lepur, Adriana ; Vrbanec, Damir ; Markotić, Alemka ; Dembić, Zlatko ; Weber, Alexander N.R ; Piantanida, Ivo ; Vugrek, Oliver ; Diken, Mustafa ; Knežević, Jelena
engleski
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro
We have previously demonstrated the nucleic acid binding capacity of phenanthridine derivatives (PHTs). Because nucleic acids are potent inducers of innate immune response through Toll-like receptors (TLRs), and because PTHs bear a structural resemblance to commonly used synthetic ligands for TLR7/8, we hypothesized that PHTs could modulate/activate immune response. We found that compound M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs and inhibits TLR3/9 activation in different cellular systems (PBMCs, HEK293 and THP-1 cell lines).
phenantridines ; TLR ; PBMCs ; cytokines ; immunomodulation
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Podaci o izdanju
27 (7)
2017.
1530-1537
objavljeno
0960-894X
10.1016/j.bmcl.2017.02.048
Povezanost rada
Temeljne medicinske znanosti