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Pregled bibliografske jedinice broj: 869473

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro


Knežević Teofilović, Natalija; Bihi, Majjoub; Radić Stojković, Marijana; Tumir, Lidija; Ester, Katja; Kralj, Marijeta; Majhen, Dragomira; Oršolić, Nada; Lepur, Adriana; Vrbanec, Damir et al.
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro // Bioorganic & medicinal chemistry letters, 27 (2017), 7; 1530-1537 doi:10.1016/j.bmcl.2017.02.048 (međunarodna recenzija, članak, znanstveni)


Naslov
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro

Autori
Knežević Teofilović, Natalija ; Bihi, Majjoub ; Radić Stojković, Marijana ; Tumir, Lidija ; Ester, Katja ; Kralj, Marijeta ; Majhen, Dragomira ; Oršolić, Nada ; Lepur, Adriana ; Vrbanec, Damir ; Markotić, Alemka ; Dembić, Zlatko ; Weber, Alexander N.R ; Piantanida, Ivo ; Vugrek, Oliver ; Diken, Mustafa ; Knežević, Jelena

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 27 (2017), 7; 1530-1537

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Phenantridines, TLR, PBMCs, cytokines, immunomodulation
(Fenantridini, TLR, PBMC, citokini, imunomodulacija)

Sažetak
We have previously demonstrated the nucleic acid binding capacity of phenanthridine derivatives (PHTs). Because nucleic acids are potent inducers of innate immune response through Toll-like receptors (TLRs), and because PTHs bear a structural resemblance to commonly used synthetic ligands for TLR7/8, we hypothesized that PHTs could modulate/activate immune response. We found that compound M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs and inhibits TLR3/9 activation in different cellular systems (PBMCs, HEK293 and THP-1 cell lines).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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