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Pregled bibliografske jedinice broj: 869473

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro


Knežević Teofilović, Natalija; Bihi, Majjoub; Radić Stojković, Marijana; Tumir, Lidija; Ester, Katja; Kralj, Marijeta; Majhen, Dragomira; Oršolić, Nada; Lepur, Adriana; Vrbanec, Damir et al.
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro // Bioorganic & medicinal chemistry letters, 27 (2017), 7; 1530-1537 doi:10.1016/j.bmcl.2017.02.048 (međunarodna recenzija, članak, znanstveni)


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Naslov
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro

Autori
Knežević Teofilović, Natalija ; Bihi, Majjoub ; Radić Stojković, Marijana ; Tumir, Lidija ; Ester, Katja ; Kralj, Marijeta ; Majhen, Dragomira ; Oršolić, Nada ; Lepur, Adriana ; Vrbanec, Damir ; Markotić, Alemka ; Dembić, Zlatko ; Weber, Alexander N.R ; Piantanida, Ivo ; Vugrek, Oliver ; Diken, Mustafa ; Knežević, Jelena

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 27 (2017), 7; 1530-1537

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
phenantridines ; TLR ; PBMCs ; cytokines ; immunomodulation

Sažetak
We have previously demonstrated the nucleic acid binding capacity of phenanthridine derivatives (PHTs). Because nucleic acids are potent inducers of innate immune response through Toll-like receptors (TLRs), and because PTHs bear a structural resemblance to commonly used synthetic ligands for TLR7/8, we hypothesized that PHTs could modulate/activate immune response. We found that compound M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs and inhibits TLR3/9 activation in different cellular systems (PBMCs, HEK293 and THP-1 cell lines).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
FP7-REGPOT-2012-2013-1

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Knežević Teofilović, Natalija; Bihi, Majjoub; Radić Stojković, Marijana; Tumir, Lidija; Ester, Katja; Kralj, Marijeta; Majhen, Dragomira; Oršolić, Nada; Lepur, Adriana; Vrbanec, Damir et al.
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro // Bioorganic & medicinal chemistry letters, 27 (2017), 7; 1530-1537 doi:10.1016/j.bmcl.2017.02.048 (međunarodna recenzija, članak, znanstveni)
Knežević Teofilović, N., Bihi, M., Radić Stojković, M., Tumir, L., Ester, K., Kralj, M., Majhen, D., Oršolić, N., Lepur, A. & Vrbanec, D. (2017) 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & medicinal chemistry letters, 27 (7), 1530-1537 doi:10.1016/j.bmcl.2017.02.048.
@article{article, year = {2017}, pages = {1530-1537}, DOI = {10.1016/j.bmcl.2017.02.048}, keywords = {phenantridines, TLR, PBMCs, cytokines, immunomodulation}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2017.02.048}, volume = {27}, number = {7}, issn = {0960-894X}, title = {1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro}, keyword = {phenantridines, TLR, PBMCs, cytokines, immunomodulation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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