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Pregled bibliografske jedinice broj: 866219

I index is not an accurate indicator of icteria in conjugated hyperbilirubinemia


Nikolac Gabaj, Nora; Miler, Marijana; Mihić, Roman
I index is not an accurate indicator of icteria in conjugated hyperbilirubinemia // Clinica chimica acta, 473 (2017), 32-34 doi:10.1016/j.cca.2017.08.013 (međunarodna recenzija, članak, znanstveni)


Naslov
I index is not an accurate indicator of icteria in conjugated hyperbilirubinemia
(II index is not an accurate indicator of icteria in conjugated hyperbilirubinemia)

Autori
Nikolac Gabaj, Nora ; Miler, Marijana ; Mihić, Roman

Izvornik
Clinica chimica acta (0009-8981) 473 (2017); 32-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Preanalytical phase ; Laboratory error ; Serum indices ; Interferences ; Icteria

Sažetak
Serum indices have become a standard in assessing degree of endogenous interferences in serum and plasma samples. The aim of this study was to evaluate accuracy of I index in comparison with total bilirubin concentration in icteric samples with ranging amount of conjugated bilirubin. This study retrospectively analyzed data from laboratory information system. Total, conjugated bilirubin and I index are measured on Abbott Architect c8000 (N=900). Agreement between total bilirubin and I index in subgroups according to proportion of direct bilirubin (< 50% and ≥50%) was investigated using Bland-Altman analysis. In samples where percentage of direct bilirubin accounts for< 50% of total bilirubin there was no statistically significant constant difference, while small proportional difference was observed (2.5%) between total bilirubin and I index. In samples where percentage of direct bilirubin accounts for ≥50% of total bilirubin, significant constant (26.6) and proportional difference (22.2%) were observed between total bilirubin and I index. I index is not accurate indicator of icteria if> 50% of bilirubin is conjugated. Manufacturers should declare icteria interference with both, bilirubin concentration and value of I index.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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