Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

KPC-Producing Klebsiella pneumoniae Isolates in Croatia: A Nationwide Survey (CROSBI ID 237188)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jelić, Marko ; Butić, Iva ; Plečko, Vanda ; Cipriš, Ivan ; Jajić, Ines ; Bejuk, Danijela ; Košćak, Iva Marinković, Sonja ; Payerl-Pal, Marina ; Andrašević-Tambić, Arjana KPC-Producing Klebsiella pneumoniae Isolates in Croatia: A Nationwide Survey // Microbial drug resistance, 22 (2016), 8; 662-667. doi: 10.1089/mdr.2015.0150

Podaci o odgovornosti

Jelić, Marko ; Butić, Iva ; Plečko, Vanda ; Cipriš, Ivan ; Jajić, Ines ; Bejuk, Danijela ; Košćak, Iva Marinković, Sonja ; Payerl-Pal, Marina ; Andrašević-Tambić, Arjana

engleski

KPC-Producing Klebsiella pneumoniae Isolates in Croatia: A Nationwide Survey

Background: In the last few years, Klebsiella pneumoniae strains producing K. pneumoniae carbapenemase (KPC) enzymes have emerged as important multidrug-resistant pathogens in hospitalized patients. This report describes KPC-producing isolates collected through the Croatian antimicrobial resistance surveillance program in the early stage of their dissemination in Croatia. Materials and Methods: Forty-eight KPC-producing K. pneumoniae isolates, collected during a period from February 2011 to August 2013, were analyzed in this study. Antimicrobial susceptibility profiles were determined using disk diffusion and E-test. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were used for epidemiological analysis. Identification of β-lactamase genes and associated antibiotic resistance mechanisms was performed by polymerase chain reaction and positive products were sequenced. Localization of blaKPC was investigated by S1 PFGE and Southern hybridization. Results: Of 40 participating centers in Croatia, KPC isolates were recorded in 9 of them. They all had multidrug-resistant phenotype, but showed varying levels of resistance to carbapenems. All isolates displayed ST258, and PFGE showed that all but one were closely related. All isolates harbored blaKPC-2. Isolate with a unique PFGE pattern produced TEM-1, while others produced TEM-116. All isolates harbored blaSHV-11, but were negative for blaCTX-M and blaAmpC genes. All isolates contain one KPC-harboring plasmid, ranging in size from ∼60 to ∼210 kb, characterized as FIIs and IncR. Conclusion: This report describes that the early stage of KPC-producing K. pneumoniae dissemination in Croatia is associated with a prolific PFGE type belonging to ST258. So far, the spread of an outbreak strain is limited to the northwest region of the country.

Croatia ; KPC ; Klebsiella pneumoniae ; ST258

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

22 (8)

2016.

662-667

objavljeno

1076-6294

1931-8448

10.1089/mdr.2015.0150

Povezanost rada

Biologija

Poveznice
Indeksiranost