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izvor podataka: crosbi !

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study. (CROSBI ID 236855)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Zimmerman, Brian ; Grošev, Darko ; Buvat, Irene ; Coca Pérez, Marco ; Frey, Eric ; Green, Alan ; Krisanachinda, Anchali ; Lassmann, Michael ; Ljungberg, Michael ; Pozzo, Lorena et al. Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study. // Zeitschrift fur Medizinische Physik, 26 (2016), 1-15. doi: 10.1016/j.zemedi.2016.03.008

Podaci o odgovornosti

Zimmerman, Brian ; Grošev, Darko ; Buvat, Irene ; Coca Pérez, Marco ; Frey, Eric ; Green, Alan ; Krisanachinda, Anchali ; Lassmann, Michael ; Ljungberg, Michael ; Pozzo, Lorena ; Quadir, Kamila ; Terán Gretter, Mariella ; Van Staden, Johan ; Poli, Gian Luca

engleski

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study.

Accurate quantitation of activity provides the basis forinternal dosimetry of targeted radionuclide therapies. Thisstudy investigated quantitative imaging capabilities at siteswith a variety of experience and equipment and assessedlevels of errors in activity quantitation in Single-PhotonEmission Computed Tomography (SPECT) and planarimaging. Participants from 9 countries took part in a com-parison in which planar, SPECT and SPECT with X raycomputed tomography (SPECT-CT) imaging were used toquantify activities of four epoxy-filled cylinders contain-ing133Ba, which was chosen as a surrogate for131I. Thesources, with nominal volumes of 2, 4, 6 and 23 mL, werecalibrated for133Ba activity by the National Institute ofStandards and Technology, but the activity was initiallyunknown to the participants. Imaging was performed ina cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated theactivities using their local standard protocols, and thenrepeated the measurements using a standardized acqui-sition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by asingle centre using a fixed protocol. In the first trial, theactivities were underestimated by about 15% with pla-nar imaging. SPECT with Chang’s first order attenuationcorrection (Chang-AC) and SPECT-CT overestimated theactivity by about 10%. The second trial showed moderateimprovements in accuracy and variability. Planar imag-ing was subject to methodological errors, e.g., in the useof a transmission scan for attenuation correction. The useof Chang-AC was subject to variability from the definitionof phantom contours. The project demonstrated the needfor training and standardized protocols to achieve goodlevels of quantitative accuracy and precision in a multi-centre setting. Absolute quantification of simple objectswith no background was possible with the strictest proto-col to about 6% with planar imaging and SPECT (withChang-AC) and within 2% for SPECT-CT.

comparison ; quantitative imaging ; SPECT ; planar

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Podaci o izdanju

26

2016.

1-15

objavljeno

0939-3889

10.1016/j.zemedi.2016.03.008

Povezanost rada

Fizika

Poveznice
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