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An improved and efficient N-acetylation of amines using choline chloride based deep eutectic solvents

An optimization of N-acetylation of various amines was performed in cholin chloride based deep eutectic solvents. First the raction was optimized regarding amine:acetic ratio and reaction time, on anthranilic acid. Then the optimizatoin was done regarding the best DES on anthranilic acid and 4-chloroaniline, where the best conditions were in combination of cholin chloride and urea or malonic acid. A series of amines was then acetylated under these conditions, in both solvents, giving an excellent results considering reaction times (10-60 min) and isolated yields up to 91%. Choline chloride based deep eutectic solvents were proven to be an excellent media for fast, selective and catalyst-free acetylation of amines.

deep eutectic solvents ; N-acetylation ; amines

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