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Pregled bibliografske jedinice broj: 861750

Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation


Oršolić, Nada
Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation // Quercetin: Food Sources, Antioxidant Properties and Health Effects / Malone, Gregory (ur.).
New York: Nova Science Publishers, Inc, 2015. str. 161-182


CROSBI ID: 861750 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation

Autori
Oršolić, Nada

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Quercetin: Food Sources, Antioxidant Properties and Health Effects

Urednik/ci
Malone, Gregory

Izdavač
Nova Science Publishers, Inc

Grad
New York

Godina
2015

Raspon stranica
161-182

ISBN
978-1-63483-595-4

Ključne riječi
mouse models of psoriasis, skin lesions, thermography, quercetin

Sažetak
Reactive oxygen species (ROS) play a role in a numbered of chronic diseases including psoriasis. Psoriasis is a chronic inflammatory, proliferative skin disease characterized by hyperkeratosis, dermal inflammatory infiltrate and increased angiogenesis. The current study examined the possible positive effects of quercetin on animal model psoriasis, induced by the Hexyl salicylate (HXS) or Di-n-Propyl Disulfide irritant (PPD) and possibility to assess usefulness of thermography in psoriatic lesion regression. We monitored the inflammation process by histopathological assessment of skin, thermographic scanning, total number of inflammatory cells in peritoneal cavity, differential analysis of cells in peritoneal cavity, macrophage spreading index, hematological and biochemical parameters, frequencies of micronucleated reticulocytes, lipid peroxidation and glutathione assay in skin, liver and kidney. Topically applied quercetin with HXS or PPD may improve psoriatic-like skin lesions by suppressing number of inflammatory cells in skin, functional activity of macrophages, and ROS production. In addition, total number of inflammatory cells in peritoneal cavity, macrophage spreading index, lipid peroxidation in liver and kidney, and enzymatic activity of ALP and AST were reduced in psoriatic mice treated with quercetin. Taken together, these results support the quercetin as an anti-inflammatory and antioxidative agent and open up new possibilities for its use in skin disorders without causing any toxic effect. Thermal imaging was realistic, and can be applicable in examining of the inflammatory process in psoriasis and in evaluating the effectiveness of quercetin and other tested substances.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Reactive oxygen species (ROS) play a role in a numbered of chronic diseases including psoriasis. Psoriasis is a chronic inflammatory, proliferative skin disease characterized by hyperkeratosis, dermal inflammatory infiltrate and increased angiogenesis. The current study examined the possible positive effects of quercetin on animal model psoriasis, induced by the Hexyl salicylate (HXS) or Di-n-Propyl Disulfide irritant (PPD) and possibility to assess usefulness of thermography in psoriatic lesion regression. We monitored the inflammation process by histopathological assessment of skin, thermographic scanning, total number of inflammatory cells in peritoneal cavity, differential analysis of cells in peritoneal cavity, macrophage spreading index, hematological and biochemical parameters, frequencies of micronucleated reticulocytes, lipid peroxidation and glutathione assay in skin, liver and kidney. Topically applied quercetin with HXS or PPD may improve psoriatic-like skin lesions by suppressing number of inflammatory cells in skin, functional activity of macrophages, and ROS production. In addition, total number of inflammatory cells in peritoneal cavity, macrophage spreading index, lipid peroxidation in liver and kidney, and enzymatic activity of ALP and AST were reduced in psoriatic mice treated with quercetin. Taken together, these results support the quercetin as an anti-inflammatory and antioxidative agent and open up new possibilities for its use in skin disorders without causing any toxic effect. Thermal imaging was realistic, and can be applicable in examining of the inflammatory process in psoriasis and in evaluating the effectiveness of quercetin and other tested substances.



POVEZANOST RADA


Projekti:
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Nada Oršolić (autor)


Citiraj ovu publikaciju

Oršolić, Nada
Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation // Quercetin: Food Sources, Antioxidant Properties and Health Effects / Malone, Gregory (ur.).
New York: Nova Science Publishers, Inc, 2015. str. 161-182
Oršolić, N. (2015) Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation. U: Malone, G. (ur.) Quercetin: Food Sources, Antioxidant Properties and Health Effects. New York, Nova Science Publishers, Inc, str. 161-182.
@inbook{inbook, author = {Or\v{s}oli\'{c}, N.}, editor = {Malone, G.}, year = {2015}, pages = {161-182}, keywords = {mouse models of psoriasis, skin lesions, thermography, quercetin}, isbn = {978-1-63483-595-4}, title = {Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation}, keyword = {mouse models of psoriasis, skin lesions, thermography, quercetin}, publisher = {Nova Science Publishers, Inc}, publisherplace = {New York} }
@inbook{inbook, author = {Or\v{s}oli\'{c}, N.}, editor = {Malone, G.}, year = {2015}, pages = {161-182}, keywords = {mouse models of psoriasis, skin lesions, thermography, quercetin}, isbn = {978-1-63483-595-4}, title = {Quercetin attenuates n-Hexyl salicylate or Di-n-Propyl Disulfide - induced skin irritation: oxidative stress and inflammation}, keyword = {mouse models of psoriasis, skin lesions, thermography, quercetin}, publisher = {Nova Science Publishers, Inc}, publisherplace = {New York} }




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