MALAKOPLAKIA IN THE DIGESTIVE TRACT OF A DOG (CROSBI ID 645009)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Gudan Kurilj, Andrea ; Huber, Doroteja ; Hohšteter, Marko ; Medven Zagradišnik, Lidija ; Šostarić-Zuckermann, Ivan-Conrado ; Beck, Ana
engleski
MALAKOPLAKIA IN THE DIGESTIVE TRACT OF A DOG
Introduction: Malakoplakia is a chronic inflammatory process, which most often affects the urinary tract in immunocompromised human patients. Spontaneously arising animal cases of malakoplakia are rare, having been reported in two pigs and a kitten. Materials and Methods: A 12-year-old male golden retriever with a 1-week history of weight loss and inappetence was humanely destroyed after clinical examination and transabdominal ultrasonography. Necropsy examination was performed and tissue samples for histopathological examination were stained with HE, periodic acid eSchiff (PAS), toluidine blue, von Kossa’s stain, Perl’s Prussian blue, Gram and Ziehl-Neelsen stains. Results: Necropsy examination revealed a thickened gastric wall (fundus and pylorus) with white, firm nodules affecting the greater omentum and gastrosplenic ligament and enlarged mesenteric lymph nodes. Histologically, severe fibrosis with multifocal round cell infiltrates mainly composed of histiocytes were present transmurally in the stomach, omentum and lymph node. Histiocytes were polygonal with abundant, granular eosinophilic cytoplasm that often contained round, basophilic cytoplasmic structures measuring 2e20 mm (MichaeliseGutmann bodies) ; some structures appeared homogeneous, while others had concentric, target-like appearance. Finely granular PAS-positive granules were present in the cytoplasm of histiocytes and a strong PAS reaction was present in nearly all of the cytoplasmic bodies. Weak toluidine blue staining was present in the cytoplasm of some histiocytes, while Perl’s Prussian blue staining was very scant. Moderate to strong von Kossa’s staining was evident in areas of abundant histiocytic infiltrates. Gram and Ziehl-Neelsen stains were negative. Conclusions: On the basis of histopathological features, this case was diagnosed as malakoplakia and to our knowledge, it is the First description of this condition in a dog.
malakoplakia, digestive tract, dog
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Podaci o prilogu
2016.
objavljeno
Podaci o matičnoj publikaciji
0021-9975
Podaci o skupu
34th Annual Meeting of the ESVP and 27th Annual Meeting of the ECVP
poster
07.09.2016-10.09.2016
Bologna, Italija
Povezanost rada
Veterinarska medicina