engleski

Osteocalcin protein sequences of Neanderthals and modern primates

We report here protein sequences of fossil hominids, from two Neanderthals dating to
about 75, 000 years old from Shanidar Cave in Iraq. These sequences, the oldest reported fossil primate protein sequences, are of bone osteocalcin, which was extracted and sequenced by using MALDI-TOF/
TOF mass spectrometry. Through a combination of direct sequencing and peptide mass mapping, we determined that Neanderthals have an osteocalcin amino acid sequence that is identical to that of modern humans. We also report complete osteocalcin sequences for chimpanzee (Pan troglodytes)and gorilla (Gorilla gorilla gorilla) and a partial sequence for orangutan (Pongo pygmaeus), all of which are previously unreported.

MALDI-TOF/TOF ; dietary adaptation ; biomolecular preservation

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