Eco-friendly rapid synthesis of 3-substituted- 2- thioxo-2, 3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent (CROSBI ID 236160)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Molnar, Maja ; Klenkar, Jelena ; Tarnai, Tena
engleski
Eco-friendly rapid synthesis of 3-substituted- 2- thioxo-2, 3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent
A series of 3-substituted-2-thioxo-2, 3- dihydroquinazolin-4(1H)-ones and 6-iodo-3- substituted-2-thioxo-2, 3-dihydroquinazolin- 4(1H)-ones were synthesized in choline chloride/urea deep eutectic solvent. Substituted 2-mercapto-4(3H)-quinazolinones were synthesized from anthranilic acid or 5- iodoanthranilic acid and appropriate isothiocyanates in good to excellent yields. Isolation of final product was easy and required no further purification. Synthesis of these compounds was rapid, selective and catalyst free, while preparation of deep eutectic solvent was easy, components are readily available, cheap and environmentally friendly.
deep eutectic solvents ; 2-thioxo-2, 3-dihydroquinazolin-4(1H)-ones ; anthranilic acid ; 5-iodoanthranilic acid ; isothiocyanate
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Podaci o izdanju
47 (11)
2017.
1040-1045
objavljeno
0039-7911
1532-2432
10.1080/00397911.2017.1291815
Povezanost rada
Kemija, Prehrambena tehnologija