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Pregled bibliografske jedinice broj: 859612

Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: binding and aggregation studies


Mao, Li; Matković, Marija; Piantanida, Ivo; Schmuck, Carsten
Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: binding and aggregation studies // Bioorganic & medicinal chemistry, 25 (2017), 6; 1875-1880 doi:10.1016/j.bmc.2017.02.006 (međunarodna recenzija, članak, znanstveni)


Naslov
Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: binding and aggregation studies

Autori
Mao, Li ; Matković, Marija ; Piantanida, Ivo ; Schmuck, Carsten

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 25 (2017), 6; 1875-1880

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Arginine mimic ; polynucleotide binding ; DNA/RNA recognition ; hydrogen bonds ; ion pair

Sažetak
An arginine mimetic, featuring a guanidiniocarbonypyrrol as artifical anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA. While the incorporation of this GCP modification did not significantly change the overall binding affinity for DNA/RNA, their interactions were more sensitive with respect to the type of polynucleotides. Peptide 4, with four GCP modifications, exhibited amazing fluorescent selectivity for AU- and (to a lesser extent) AT- sequences. GC-containing DNA showed much lower response. Additionally, exclusively tri-GCP modified peptide 3 showed intriguing exciton-coupled bisignate ICD bands for all studied DNA/RNA which suggested that a well-defined GCP-dimer bound into DNA/RNA groove

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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