Fate and Effect of Engineered (Manufactured) Nanomaterials on Marine Ecosystem (CROSBI ID 644660)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Jakšić, Željko
engleski
Fate and Effect of Engineered (Manufactured) Nanomaterials on Marine Ecosystem
In the recent two decades the Engineered (Manufactured) Nanomaterials (ENMs) of widespread use become one of the marine contaminants of emerging concern. Their versatile physicochemical characteristics influence their fate and effect in marine ecosystem, and represent a novel challenges to the established suit of hazard assessment tests. The presentation will describe the pathways of ENMs in the marine ecosystem (water column and sediment), their fate and behaviour as well as interactions with macromolecules and living organisms. Special attention will be devoted to the physico-chemical processes of ENMs, like adsorption, dissolution, transformations and homo/hetero-aggregation in marine environment. The comprehensive state-of- the-art overview of marine nanotoxicology research (test systems and model organisms, uptake routes and mechanisms, body and/or intracellular trafficking/translocation/storage and bioaccumulation ; trophic transfer ; specific targets of effects, mode of actions and mechanisms of toxicity, sub-lethal effects and acute toxicity) will be outlined by case studies results presentation and ways forward discussed. The important processes such as immune response, oxidation stress and genotoxic effects will be explained and comment in details. Spatial emphasis will be given to question how environmental conditions determine exposure to and effect of ENMs. Furthermore, identification and avoidance of potential artefacts and misinterpretations in nano(eco)toxicity measurements will be pointed out. Finally, the lecture will provide an overview of the ENMs regulatory assessment (REACH, OECD) and future research needs/challenges (integration of ENMs chemistry, experimental modelling, high throughput screening, systems toxicology approach, realistic exposure and chronic effects/responses across different levels of biological organisations, effects on sediment species).
engineered (manufactured) nanomaterial ; marine nano(eco)toxicology, acute toxicology, mode of action, sub-lethal effects, physico-chemical processes, regulatory assessment
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Podaci o prilogu
21-21.
2016.
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objavljeno
Podaci o matičnoj publikaciji
Arhiv za higijenu rada i toksikologiju
Durgo, Ksenija
Zagreb: Institut za medicinska istraživanja i medicinu rada
0004-1254
1848-6312
Podaci o skupu
Croatian Congress of Toxicology with International Participation CROTOX 2016
pozvano predavanje
09.10.2016-12.10.2016
Poreč, Hrvatska
Povezanost rada
Biotehnologija, Geologija, Kemija