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Pregled bibliografske jedinice broj: 856443

Changes in gene structure and protein expression of DVL1, DVL2, DVL3 and transcription factors TCF1 and LEF1 in glioblastoma


Kafka, Anja; Pećina-Šlaus, Nives
Changes in gene structure and protein expression of DVL1, DVL2, DVL3 and transcription factors TCF1 and LEF1 in glioblastoma // PhD Day 2015 Abstract Book
Zagreb, Hrvatska, 2015. str. 27-27 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Changes in gene structure and protein expression of DVL1, DVL2, DVL3 and transcription factors TCF1 and LEF1 in glioblastoma

Autori
Kafka, Anja ; Pećina-Šlaus, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
PhD Day 2015 Abstract Book / - , 2015, 27-27

Skup
Dan doktorata 2015/PhD Day 2015

Mjesto i datum
Zagreb, Hrvatska, 22.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Wnt signaling pathway ; glioblastoma ; Dishevelled (DVL), TCF1, LEF1

Sažetak
Glioblastoma are the most common and the most aggressive tumors of central nervous system and are classified as grade IV astrocytoma by the criteria of the WHO. Wnt signalling pathway is basic cellular pathway whose misregulation plays important roles in tumorigenesis. Dishevelled (DVL) is cytoplasmatic phosphoprotein, who comes first in downstream cascade from Frizzled (Fz) receptor. When the signalization mediated by DVL is disrupted, it consequently induce transcription of target genes regulated by transcription factor TCF1 and LEF1 which results in tumor development and progression. In the present study changes of three homolog genes of Dishevelled (DVL1, DVL2 and DVL3) and their protein expression were investigated in glioblastoma

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb