engleski

Lipid-based Nanopharmaceuticals in Antimicrobial Therapy

Nanotechnology and its direct application in medicine offer a platform for advanced therapeutic strategies against infections. The small size of nanosystems (nanocarriers) distinguishes their features from other delivery systems since nanocarriers may penetrate biological membranes, improve drug bioavailability, assure cellular internalization and often achieve targeted delivery of various drugs, including antimicrobials. Lipid-based nanosystems, in addition to their confirmed biodegradability and biocompatibility, allow fusion with infectious microbes, facilitating the release of the drug intracellularly. This chapter summarizes the most studied lipid-based nanocarriers, their applications via various routes of drug administration, their advantages in comparison to other drug dosage forms and delivery systems, the toxicity issues and current limitations. Based on authors’ experience in the research related to therapy of vaginal and skin infections, those routes are discussed in more details. The promising lines in lipid-based nanopharmaceutical research are highlighted.

Nanomedicine ; Infection ; Antimicrobial resistance ; Liposomes ; Solid lipid nanoparticles ; Nanostructured lipid carriers

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