Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease (CROSBI ID 235274)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ventham, N. T. ; Kennedy, N. A. ; Adams, A. T. ; Kalla, R. ; Heath, S. ; O'Leary, K. R. ; Drummond, H. ; IBD BIOM, consortium ; IBD CHARACTER, consortium ; Wilson, D. C. ; Gut, I. G. ; Nimmo, E. R. ; Satsangi, J.
engleski
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisulphite sequencing. We replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2 and TXK) in an independent cohort. Using paired genetic and epigenetic data, we delineate methylation quantitative trait loci ; VMP1/microRNA-21 methylation associates with two polymorphisms in linkage disequilibrium with a known IBD susceptibility variant. Separated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8+ T cells, but not other cell types. Thus, site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression.
inflammatory bowel disease ; DNA methylation ; epigenetics
Autori članovi IBD BIOM consortiuma Lauc, Gordan ; Campbell, Harry ; McGovern, Dermot P.B. ; Annese, Vito ; Zoldoš, Vlatka ; Permberton, Iain K. ; Wuhrer, Manfred ; Kolarich, Daniel ; Fernandes, Daryl L. ; Theorodorou, Evropi ; Merrick, Victoria ; Spencer, Daniel I. ; Gardner, Richard A. ; Doran, Ray ; Shubhakar, Archana ; Boyapati, Ray ; Rudan, Igor ; Lionetti, Paolo ; Trbojević Akmačić, Irena ; Krištić, Jasminka ; Vučković, Frano ; Štambuk, Jerko ; Novokmet, Mislav ; Pučić-Baković, Maja ; Gornik, Olga ; Andriulli, Angelo ; Cantoro, Laura ; Sturniolo, Giancarlo ; Fiorino, Gionata ; Manetti, Natalia ; Latiano, Anna ; Kohn, Anna ; D’Incá, Renata ; Danese, Silvio ; Arnott, Ian D. ; Noble, Colin L. ; Lees, Charlie W. ; Shand, Alan G. ; Ho, Gwo-Tzer ; Dunlop, Malcolm G. ; Murphy, Lee ; Gibson, Jude ; Evenden, Louise ; Wrobe, Nicola l. ; Gilchrist, Tamara ; Fawkes, Angie ; Kammeijer, Guinevere S.M. ; Clerc, Florent ; de Haan, Noortje ; Vojta ; Aleksandar ; Samaržija, Ivana ; Markulin, Dora ; Klasić, Marija ; Dobrinić, Paula ; Aulchenko, Yurii ; van den Heuve, Tim ; Jonkers, Daisy ; Pierik, Marieke. Autori članovi IBD CHARACTER consortiuma Vatn, Simen ; Ricanek,
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano