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Pregled bibliografske jedinice broj: 855167

Association Rates of Membrane-Coupled Cell Adhesion Molecules


Bihr, Timo; Fenz, Susanne; Sackmann, Erich; Merkel, Rudolf; Seifert, Udo; Sengupta, Kheya; Smith, Ana-Sunčana
Association Rates of Membrane-Coupled Cell Adhesion Molecules // Biophysical journal, 107 (2014), 11; L33-L36 doi:10.1016/j.bpj.2014.10.033 (međunarodna recenzija, pismo, znanstveni)


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Naslov
Association Rates of Membrane-Coupled Cell Adhesion Molecules

Autori
Bihr, Timo ; Fenz, Susanne ; Sackmann, Erich ; Merkel, Rudolf ; Seifert, Udo ; Sengupta, Kheya ; Smith, Ana-Sunčana

Izvornik
Biophysical journal (0006-3495) 107 (2014), 11; L33-L36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
cell adhesion ; ligand-receptor pair ; protein complexation

Sažetak
Thus far, understanding how the confined cellular environment affects the lifetime of bonds, as well as the extraction of complexation rates, has been a major challenge in studies of cell adhesion. Based on a theoretical description of the growth curves of adhesion domains, we present a new (to our knowledge) method to measure the association rate kon of ligand-receptor pairs incorporated into lipid membranes. As a proof of principle, we apply this method to several systems. We find that the kon for the interaction of biotin with neutravidin is larger than that for integrin binding to RGD or sialyl Lewisx to E-selectin. Furthermore, we find kon to be enhanced by membrane fluctuations that increase the probability for encounters between the binders. The opposite effect on kon could be attributed to the presence of repulsive polymers that mimic the glycocalyx, which points to two potential mechanisms for controlling the speed of protein complexation during the cell recognition process.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ana Sunčana Smith (autor)

Citiraj ovu publikaciju

Bihr, Timo; Fenz, Susanne; Sackmann, Erich; Merkel, Rudolf; Seifert, Udo; Sengupta, Kheya; Smith, Ana-Sunčana
Association Rates of Membrane-Coupled Cell Adhesion Molecules // Biophysical journal, 107 (2014), 11; L33-L36 doi:10.1016/j.bpj.2014.10.033 (međunarodna recenzija, pismo, znanstveni)
Bihr, T., Fenz, S., Sackmann, E., Merkel, R., Seifert, U., Sengupta, K. & Smith, A. (2014) Association Rates of Membrane-Coupled Cell Adhesion Molecules. Biophysical journal, 107 (11), L33-L36 doi:10.1016/j.bpj.2014.10.033.
@article{article, year = {2014}, pages = {L33-L36}, DOI = {10.1016/j.bpj.2014.10.033}, keywords = {cell adhesion, ligand-receptor pair, protein complexation}, journal = {Biophysical journal}, doi = {10.1016/j.bpj.2014.10.033}, volume = {107}, number = {11}, issn = {0006-3495}, title = {Association Rates of Membrane-Coupled Cell Adhesion Molecules}, keyword = {cell adhesion, ligand-receptor pair, protein complexation} }
@article{article, year = {2014}, pages = {L33-L36}, DOI = {10.1016/j.bpj.2014.10.033}, keywords = {cell adhesion, ligand-receptor pair, protein complexation}, journal = {Biophysical journal}, doi = {10.1016/j.bpj.2014.10.033}, volume = {107}, number = {11}, issn = {0006-3495}, title = {Association Rates of Membrane-Coupled Cell Adhesion Molecules}, keyword = {cell adhesion, ligand-receptor pair, protein complexation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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