Macro- and microelement in rat liver, kidney, and brain tissues: sex differences and effect of blood removal by perfusion in vivo (CROSBI ID 643832)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Orct, Tatjana ; Jurasović, Jasna ; Micek, Vedran ; Karaica, Dean ; Sabolić, Ivan
engleski
Macro- and microelement in rat liver, kidney, and brain tissues: sex differences and effect of blood removal by perfusion in vivo
The concentrations of macro- and microelements in tissues could be sex-related and affected by blood retained in dissected organs. To test these hypotheses, in 3-mo old female and male rats, the concentrations of various elements were measured in the blood-containing (nonperfused) and blood- free (perfused in vivo with an elements-free buffer) liver, kidney, and brain (N=5 in each group). In these organs, 6 macroelements and 15 microelements were determined by ICP-MS. In non- perfused organs, female-dominant differences were observed for Fe, Se, and I in the liver ; Fe, Co, Zn, Cd, and Li in the kidney ; and As and Li in the brain. In blood-free organs, similar differences were detected for: Mg, K, Fe, Mn, Cu, Se, I, and Cd in the liver ; Fe, Co, and Li in the kidney ; and none in the brain. In females, the perfused liver, kidney, and brain had significantly lower concentrations of 4 (Na, Ca, As, B), 5 (Na, K, I, As, Li), and 2 (Fe, As) elements, and higher concentrations of 10 (Mg, P, S, K, Mn, Cu, Zn, Cd, Hg, Li), 4 (Co, Pb, Cd, Hg), and 7 (Mg, S, K, Zn, Se, I, Li) elements. In males, perfusion caused lower concentrations of 4 (Na, Ca, As, B), 7 (Na, Ca, Fe, I, As, Hg, Li), and 2 (Fe, As), and higher concentrations of 1 (Li), 1 (Zn), and 7 (Mg, P, S, K, Zn, I, Li) elements in the liver, kidney, and brain, respectively. Therefore, residual blood in organs can significantly influence the tissue concentrations of various elements and their sex- dependency. This work was financially supported by Project No. 1481 Aging-related Expression of Membrane Transporters in Rat (AGEMETAR), funded by the Croatian Science Foundation.
gender differences ; ICP-MS multielement analysis ; perfusion ; rat organs
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Podaci o prilogu
50-50.
2016.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Arhiv za higijenu rada i toksikologiju
Kopjar, Nevenka
0004-1254
1848-6312
Podaci o skupu
5th Croatian Congress of Toxicology with International Participation CROTOX 2016
poster
09.10.2016-12.10.2016
Poreč, Hrvatska