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Pregled bibliografske jedinice broj: 854966

Razvoj metode za određivanje onečišćenja u nepafenak djelatnoj farmaceutskoj tvari kromatografijom superkritičnih fluida


Mislav Runje; Olga Malev; Irena Raič; Igor Avdejev; Sandra Babić
Razvoj metode za određivanje onečišćenja u nepafenak djelatnoj farmaceutskoj tvari kromatografijom superkritičnih fluida // XVI. Ruzickini dani “DANAS ZNANOST – SUTRA INDUSTRIJA"
Vukovar, Hrvatska, 2016. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 854966 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Razvoj metode za određivanje onečišćenja u nepafenak djelatnoj farmaceutskoj tvari kromatografijom superkritičnih fluida
(Developlment of method for determination of impurities in nepafenac by supercritical fluid chromatography)

Autori
Mislav Runje ; Olga Malev ; Irena Raič ; Igor Avdejev ; Sandra Babić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
XVI. Ruzickini dani “DANAS ZNANOST – SUTRA INDUSTRIJA"

Mjesto i datum
Vukovar, Hrvatska, 21-23.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nepafenak; kromatografija supekritičnih fluida; onečišćenja
(nepafenac; supercritical fluid chromatography; impurities)

Sažetak
Nepafenac is chemically described as 2-amino-3-benzoylbenzeneacetamide manufactured as a 0.1% suspension for topical ophthalmic use [1] and it belongs to a group of nonsteroidal anti-inflammatory drugs (NSAID). A novel simple, fast and efficient supercritical fluid chromatography (SFC) method was developed and compared with reversed-phase liquid chromatography (RPLC) method for the separation and determination of impurities in Nepafenc [2-3]. Overall satisfactory resolutions and peak shapes for Nepafenac, 2-aminobenzophenone, Cl-thionepafenac, Thionepafenac, Cl-Nepafenac, Hydroxy Nepafenac and Cyclic Nepafenac were obtained by optimization of the chromatography system. With the gradient elution of mobile phase, all of the impurities and the active ingredient were separated within 6 min. Taking full advantage of features of SFC (such as particular selectivity, non-sloping baseline in gradient elution, and without solvent injection effects), the method was successfully used for determination of impurities in Nepafenac. More impurity peaks were detected, better resolution was achieved and much less analysis time was needed in comparison with conventional RPLC methods. The developed SFC method is validated with respect to specificity, LOD, LOQ, linearity, precision, accuracy and robustness.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove:
PLIVA HRVATSKA d.o.o.

Profili:

Avatar Url Irena Radić (autor)

Avatar Url Olga Malev (autor)

Citiraj ovu publikaciju

Mislav Runje; Olga Malev; Irena Raič; Igor Avdejev; Sandra Babić
Razvoj metode za određivanje onečišćenja u nepafenak djelatnoj farmaceutskoj tvari kromatografijom superkritičnih fluida // XVI. Ruzickini dani “DANAS ZNANOST – SUTRA INDUSTRIJA"
Vukovar, Hrvatska, 2016. (poster, međunarodna recenzija, sažetak, znanstveni)
Mislav Runje, Olga Malev, Irena Raič, Igor Avdejev & Sandra Babić (2016) Razvoj metode za određivanje onečišćenja u nepafenak djelatnoj farmaceutskoj tvari kromatografijom superkritičnih fluida. U: XVI. Ruzickini dani “DANAS ZNANOST – SUTRA INDUSTRIJA".
@article{article, year = {2016}, keywords = {nepafenak, kromatografija supekriti\v{c}nih fluida, one\v{c}i\v{s}\'{c}enja}, title = {Razvoj metode za odre\djivanje one\v{c}i\v{s}\'{c}enja u nepafenak djelatnoj farmaceutskoj tvari kromatografijom superkriti\v{c}nih fluida}, keyword = {nepafenak, kromatografija supekriti\v{c}nih fluida, one\v{c}i\v{s}\'{c}enja}, publisherplace = {Vukovar, Hrvatska} }
@article{article, year = {2016}, keywords = {nepafenac, supercritical fluid chromatography, impurities}, title = {Developlment of method for determination of impurities in nepafenac by supercritical fluid chromatography}, keyword = {nepafenac, supercritical fluid chromatography, impurities}, publisherplace = {Vukovar, Hrvatska} }




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