engleski

Expression patterns of Wnt signaling key components: Dishevelleds, transcription factors TCF/LEF and antagonist SFRP3 in astrocytic brain tumors

Recently it has become evident that human astrocytic tumors’ growth is driven by complex signaling networks. Wnt signaling is a crucial factor in the development of many cancers and we believe that aberrant Wnt signaling has an important role in the development of astrocytic brain tumors, too. Since molecular and genetic landscapes of human astrocytic brain tumors still need elucidation we decided to study key players of Wnt signaling, dishevelleds (DVL1, DVL2, DVL3), TCF1 and LEF1 transcription factors, and SFRP3, an antagonist of Wnt signaling, in the set of human astrocytic brain tumors. Genetic changes were analyzed by polymerase chain reaction/loss of heterozygosity (LOH) and protein expressions by immunohistochemistry.

Wnt signaling ; Dishevelleds ; transcription factors TCF/LEF ; SFRP3 ; astrocytic brain tumors

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