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Pregled bibliografske jedinice broj: 853952

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling


Pećina-Šlaus, Nives; Kafka, Anja; Lechpammer, Mirna
Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling // Cancers, 8 (2016), 7; 67-1 doi:10.3390/cancers8070067 (međunarodna recenzija, članak, znanstveni)


Naslov
Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling

Autori
Pećina-Šlaus, Nives ; Kafka, Anja ; Lechpammer, Mirna

Izvornik
Cancers (2072-6694) 8 (2016), 7; 67-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Meningioma ; Wnt signalling ; meningioma genetics ; E-cadherin ; APC ; beta-catenin ; AXIN1 ; p53

Sažetak
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the brain and the spinal cord. Most meningiomas have benign clinical behaviour and are classified as grade I by World Health Organization (WHO). However, up to 20% histologically classified as atypical (grade II) or anaplastic (grade III) are associated with higher recurrent rate and have overall less favourable clinical outcome. Recently, there is emerging evidence that multiple signalling pathways including Wnt pathway contribute to the formation and growth of meningiomas. In the review we present the synopsis on meningioma histopathology and genetics and discuss our research regarding Wnt in meningioma. Epithelial-to-mesenchymal transition, a process in which Wnt signalling plays an important role, is shortly discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-6625 - Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji (Nives Pećina-Šlaus, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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