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Pregled bibliografske jedinice broj: 852771

ELF5 transcription factor expression during gestation in humans and rats - an immunohistochemical analysis


Jurković, Ivana; Geček, Iva; Škrtić, Anita; Zmijanac Partl, Jasenka; Nikuševa Martić, Tamara; Šerman, Alan; Galešić Ljubanović, Danica; Šerman, Ljiljana
ELF5 transcription factor expression during gestation in humans and rats - an immunohistochemical analysis // Journal of maternal-fetal & neonatal medicine, 2 (2016), 1-6 doi:10.1080/14767058.2016.1210596 (međunarodna recenzija, članak, znanstveni)


Naslov
ELF5 transcription factor expression during gestation in humans and rats - an immunohistochemical analysis

Autori
Jurković, Ivana ; Geček, Iva ; Škrtić, Anita ; Zmijanac Partl, Jasenka ; Nikuševa Martić, Tamara ; Šerman, Alan ; Galešić Ljubanović, Danica ; Šerman, Ljiljana

Izvornik
Journal of maternal-fetal & neonatal medicine (1476-7058) 2 (2016); 1-6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ELF5 ; IUGR ; gestational diabetes ; placenta ; rat

Sažetak
OBJECTIVE: The purpose of this study was to measure immunohistochemically the expression of ELF5 protein in term human and rat placentas and in human placentas associated with gestational diabetes (GD) and intrauterine growth restriction (IUGR). METHODS: The results were quantitated stereologically using the stereological variable of volume density. A semiquantitative analysis was performed independently by a certified pathologist. RESULTS: Total expression of ELF5 protein was higher in pathological pregnancies than in corresponding control term placentas, with both methods of quantifications showing similar results. In addition, ELF5 expression was also higher in connective tissue and blood vessels in chorionic villi in IUGR placentas (but not in GD placentas) compared to healthy controls. ELF5 is higher in placenta as a whole and in most of its components in both pathologies. The two exceptions are chorionic plates in IUGR and decidua in GD, where its expression is lower than in healthy controls. CONCLUSIONS: We have shown that IUGR and GD are associated with significantly increased levels of ELF5 protein in placentas, which suggests that ELF5 may play an important role in normal placentation. However, these are term placentas and to study ELF5 in premature births would give better insight into human placentation in health and disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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