Late Complications and Quality of Life after Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation (CROSBI ID 234277)
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Podaci o odgovornosti
Clavert, Aline ; Perić, Zinaida ; Brissot, Eolia ; Malard, Florent ; Guillaume, Thierry ; Delaunay, Jacques ; Dubruille, Viviane ; Le Gouill, Steven ; Mahe, Beatrice ; Gastinne, Thomas ; Blin, Nicolas ; Harousseau, Jean-Luc ; Moreau, Philippe ; Milpied, Noel ; Mohty, Mohamad ; Chevallier, Patrice
engleski
Late Complications and Quality of Life after Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation
Late complications (LC) and quality of life (QOL) were analyzed in 110 adult patients who underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) and were alive for more than 2 years after allo-SCT. Overall survival of these patients was 93% (95% confidence interval [CI], 88% to 99%) and 81% (95% CI, 71% to 94%) at 5 and 10 years, respectively. The primary cause of death was a recurrence of primary malignancy. With a median follow-up of 4.6 years (range, 2 to 12.1), chronic graft-versus-host disease (cGVHD) was the most prevalent late effect, with a cumulative incidence of 66% (95% CI, 57% to 74%) at 10 years. Cardiovascular complications were the most prevalent LC with a cumulative incidence of 47% (95% CI, 35% to 59%), followed by pulmonary complications with a cumulative incidence of 33% (95% CI, 21% to 46%) and renal impairment with a cumulative incidence of 34% (95% CI, 25% to 43%) at 10 years. Secondary malignancies occurred with a cumulative incidence of 11% (95% CI, 5% to 20%) at 10 years. In this series, 61 patients (55%) responded to QOL survey. With the use of European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 and Functional Assessment of Cancer Therapy-Bone Marrow Transplant questionnaires, most of the patients reported good to excellent QOL and patients with cGVHD had significantly lower QOL than patients without cGVHD. In conclusion, QOL after RIC is comparable to that seen after myeloablative conditioning, while the natural history of LC after RIC appears to be different from that described in the standard myeloablative setting, warranting further research in this field.
Long-term effects ; Quality of life ; Reduced-intensity conditioning
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Podaci o izdanju
23 (1)
2016.
140-146
objavljeno
1083-8791
10.1016/j.bbmt.2016.10.011
Povezanost rada
Kliničke medicinske znanosti