engleski

Photooxidation of a novel potentially persistent micropollutant in water

Clinical trials rarely involve an extensive study on the environmental impact of the newly developed pharmaceuticals. Therefore it is beneficiary to study the impact of novel pharmaceuticals in the environment and also means of their removal. Such a novel pharmaceutical is memantine hydrochloride, used in treatment of Parkinsons' and Alzheimer's disease. The molecular properties of memantine indicate that it could be a potentially persistent micropollutant and prone to bioaccumulation. Advanced oxidation processes (AOPs), relying on the generation of highly reactive species, primarily hydroxyl radicals, shown to be promising for the degradation of vast array of recalcitrant (micro)pollutants in water. In this study, the effectiveness of UV-C/H2O2 process, a photochemical AOP, which consider the application of UV irradiation source(s) and addition of strong oxidants, for memantine degradation was investigated. Within the study, the influence of key operational parameters of applied UV-C/H2O2 treatment ; pH and [H2O2], on memantine degradation kinetics was investigated by the means of design of experiment and response surface modeling approach. Furthermore, the mineralization kinetics, and the changes in biodegradability and toxicity toward Vibrio fishceri during applied UV-C/H2O2 treatment of memantine in water were studied.

pharmaceuticals ; memantine ; photochemical AOP ; biodegradability ; toxicity

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