engleski

Occupational airborne allergic contact dermatitis from azithromycin

A 32-year-old pharmaceutical worker, employed for 13 years in the synthesis of antibiotics, was referred with forearm and face symptoms. For the past 3 years, he had been loading reactors at 3 different stages of azithromycin synthesis and has been exposed to airborne powders. He wore overolls and latex gloves. Symptoms had persisted for a year in the form of pruritus, erythema, vesicles, and scaling of the face and forearms. He had no previous history of respiratory or dermal allergy. Patch tests with European standard series plus latex allergen (ALK-Abello, Denmark) were negative at D2 and D3. Prick tests with common inhalatory allergens were also negative and the total serum IgE was within the normal range (55 kU/L). A patch test with pure azithromycin was ++ at D2 and D3, and negative in 5 non-atopic control subjects. A week of workplace exposure confirmed progressive worsening of skin symptoms, which cleared after cessation of such exposure.

azithromycin; macrolide; antibiotics; allergic contact dermatitis; occupational

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