engleski

The activity of anidulafungin against clinical isolates of Candida spp.

Anidulafungin belongs to a unique class of new antifungals known as echinocandins. Resistance to anidulafungin is emerging, especially in non-albicans Candida isolates. The susceptibility of 80 clinical Candida isolates to anidulafungin and fluconazole was determined by E-test on RPMI agar with 2% glucose using EUCAST breakpoints. Clinical isolates from different clinical specimens were collected in first quarter of 2016. Colection included 31 C. albicans, while most non-albicans isolates belonged to C. glabrata, C. parapsilosis, C. tropicalis and C. krusei species. Almost all C. albicans strains were susceptible to fluconazole and anidulafungin (30/31), while majority of non-albicans isolates were resistant to fluconazole (30/49). Resistance or decreased sensitivity to anidulafungin was detected in 7 non-albicans strains, particulary in C. parapsilosis. The MIC50 and the MIC90 values for anidulafungin for non-albicans isolates were 0.012 mg/l or 0.906 mg/l, respectively.

candida; anidulafungin

supported by "Molecular mechanisms of bacterial pathogenesis and response to stress" (M.A. Grant No. 13.06.1.1.07. from the University of Rijeka, Croatia)