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Pregled bibliografske jedinice broj: 848358

Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology


Alebić, Miro Šimun; Stojanović, Nataša; Pavičić Baldani, Dinka; Smirčić Duvnjak, Lea
Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology // Endocrine (Basingstoke), 54 (2016), 3; 798-807 doi:10.1007/s12020-016-1062-y (međunarodna recenzija, članak, znanstveni)


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Naslov
Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology

Autori
Alebić, Miro Šimun ; Stojanović, Nataša ; Pavičić Baldani, Dinka ; Smirčić Duvnjak, Lea

Izvornik
Endocrine (Basingstoke) (1355-008X) 54 (2016), 3; 798-807

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Polycystic ovary syndrome ; menstrual cycle ; anovulation ; triglycerides ; insulin resistance

Sažetak
This cross-sectional study aimed to investigate the association between menstrual cycle lenght (MCL) and metabolic parameters in non-hyperandrogenic women with polycystic ovarian morphology (non-HA-PCOM), n=250.Metabolic profiles of all participants were evaluated using anthropometric parameters (body mass index, waist circumference), parameters of dyslipidemia (total cholesterol, HDL-cholesterol, triglycerides) and markers of insulin resistance (fasting insulin, HOMA-IR). The association between MCL and cardiometabolic risk factors such as insulin resistance, dyslipidemia and obesity were investigated.In non-HA-PCOM women, MCL was associated with hypertriglyceridemia and insulin resistance independently of BMI. Moreover, MCL added value to BMI in predicting hypertriglyceridemia.The optimal MCL cut-off value for identifying of non-HA-PCOM women at metabolic risk was found to be 45 days. Metabolic profile of non-HA-PCOM women (n=75) with MCL >45 days was similar to that of hyperandrogenic women with PCOM (n=138) while metabolic profile of non-HA-PCOM women with MCL ≤45 days (n=112) was similar to that of controls (n=167). Non-HA-PCOM women with MCL >45 days had higher prevalence of cardiometabolic risk factors compared to those with MCL ≤45 days. Non-HA-PCOM women are not metabolically homogeneous. MCL is an easy-to-obtain clinical parameter positively associated with the probability of unfavorable metabolic status in non-HA-PCOM women. MCL cut-off value of 45 days was found to have the best capacity in discriminating non-HA-PCOM women with and without metabolic derangement(s) corroborating in favor of the cardiometabolic risk factors screening and management in non-HA-PCOM women with MCL >45 days through strategies for prevention of cardiovascular disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Alebić, Miro Šimun; Stojanović, Nataša; Pavičić Baldani, Dinka; Smirčić Duvnjak, Lea
Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology // Endocrine (Basingstoke), 54 (2016), 3; 798-807 doi:10.1007/s12020-016-1062-y (međunarodna recenzija, članak, znanstveni)
Alebić, M., Stojanović, N., Pavičić Baldani, D. & Smirčić Duvnjak, L. (2016) Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology. Endocrine (Basingstoke), 54 (3), 798-807 doi:10.1007/s12020-016-1062-y.
@article{article, year = {2016}, pages = {798-807}, DOI = {10.1007/s12020-016-1062-y}, keywords = {Polycystic ovary syndrome, menstrual cycle, anovulation, triglycerides, insulin resistance}, journal = {Endocrine (Basingstoke)}, doi = {10.1007/s12020-016-1062-y}, volume = {54}, number = {3}, issn = {1355-008X}, title = {Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology}, keyword = {Polycystic ovary syndrome, menstrual cycle, anovulation, triglycerides, insulin resistance} }
@article{article, year = {2016}, pages = {798-807}, DOI = {10.1007/s12020-016-1062-y}, keywords = {Polycystic ovary syndrome, menstrual cycle, anovulation, triglycerides, insulin resistance}, journal = {Endocrine (Basingstoke)}, doi = {10.1007/s12020-016-1062-y}, volume = {54}, number = {3}, issn = {1355-008X}, title = {Metabolic implications of menstrual cycle length in non-hyperandrogenic women with polycystic ovarian morphology}, keyword = {Polycystic ovary syndrome, menstrual cycle, anovulation, triglycerides, insulin resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


Citati:





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