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Assessment of Environmental and Hereditary Influence on Development of Pituitary Tumors Using Dermatoglyphic Traits and Their Potential as Screening Markers (CROSBI ID 233613)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Gradišer, Marina ; Matovinović Osvatić, Martina ; Dilber, Dario ; Bilić-Čurčić, Ines Assessment of Environmental and Hereditary Influence on Development of Pituitary Tumors Using Dermatoglyphic Traits and Their Potential as Screening Markers // International journal of environmental research and public health, 13 (2016), 330-330. doi: 10.3390/ijerph13030330

Podaci o odgovornosti

Gradišer, Marina ; Matovinović Osvatić, Martina ; Dilber, Dario ; Bilić-Čurčić, Ines

engleski

Assessment of Environmental and Hereditary Influence on Development of Pituitary Tumors Using Dermatoglyphic Traits and Their Potential as Screening Markers

The aim of this study was to assess environmental and hereditary influence on development of pituitary tumors using dermatoglyphic traits. The study was performed on 126 patients of both genders with pituitary tumors (60 non-functional and 66 functional pituitary tumor patients) in comparison to the control group of 400 phenotypically healthy individuals. Statistical analysis of quantitative and qualitative traits of digito- palmar dermatoglyphics was performed, and hormonal status was determined according to the standard protocols. Although we did not find markers that could specifically distinguish functional from non-functional tumors, we have found markers predisposing to the development of tumors in general (a small number of ridges between triradius of both hands, a smaller number of ridges between the triradius of c–d rc R), those for endocrine dysfunction (increased number of arches and reduced number of whorls, difference of pattern distribution in the I3 and I4 interdigital space), and some that could potentially be attributed to patients suffering from pituitary tumors (small number of ridges for variables FRR 5, smaller number of ridges in the FRL 4 of both hands and difference of pattern distribution at thenar of I1 and I2 interdigital space). The usage of dermatoglyphic traits as markers of predisposition of pituitary tumor development could facilitate the earlier detection of patients in addition to standard methods, and possibly earlier treatment and higher survival rate. Finally, our results are consistent with the hypothesis about multifactorial nature of pituitary tumor etiology comprised of both gene instability and environmental factors.

dermatoglyphic traits ; functional pituitary tumors ; non-functional pituitary tumors ; early detection ; multifactorial etiology

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Podaci o izdanju

13

2016.

330-330

objavljeno

1660-4601

10.3390/ijerph13030330

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost