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Pregled bibliografske jedinice broj: 847181

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk


Lu, Yingchang; Day, Felix R; ...; Kolčić, Ivana; ...; Polašek, Ozren; ...; Smolej Narančić, Nina; ...; Rudan, Igor et al.
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk // Nature Communications, 7 (2016), 10495-1 doi:10.1038/ncomms10495 (međunarodna recenzija, članak, znanstveni)


Naslov
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Autori
Lu, Yingchang ; Day, Felix R ; ... ; Kolčić, Ivana ; ... ; Polašek, Ozren ; ... ; Smolej Narančić, Nina ; ... ; Rudan, Igor ; ... ; Loos, Ruth J.F.

Izvornik
Nature Communications (2041-1723) 7 (2016); 10495-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Body fat ; cardiometabolic traits ; genome-wide association study ; meta-analysis

Sažetak
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%)in up to 100, 716 individuals. Twelve loci reached genome-wide significance (P<5x10 -8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongy associaed with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Nina Smolej-Narančić, )
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-IP-2013-11-8875 - Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac (Ozren Polašek, )

Ustanove
Institut za antropologiju,
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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