Screening of TORCH infections during pregnancy in Primorsko-Goranska county (CROSBI ID 642326)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Peruč, Dolores ; Udović-Gobić Silvana, Volarević Nilia, Pružinec Popović Blanka
engleski
Screening of TORCH infections during pregnancy in Primorsko-Goranska county
TORCH syndrome [Toxoplasma gondii (TG), Other agents, Rubella (RV), Cytomegalovirus (CMV) and Herpes Simplex virus (HSV)] includes the most common congenital and perinatal infections. OBJECTIVES: 1. To determine the frequency of acute infections with TORCH agents among pregnant women. 2. To determine the percentage of pregnant women that have never been infected with TORCH agents. SAMPLES AND METHODS: We retrospectively analyzed the results of analysis of serum samples collected from pregnant women in Primorsko-Goranska County during 2015. Serum samples were tested for the presence of IgM and IgG antibodies against TG (n=2174), CMV (n=1159), RV (n=503), VZV (n=17), HSV-1 (n=302) and HSV-2 (n=297) using conventional diagnostic kits. Additionally, serum samples were tested for the presence of HBsAg (n=2091), anti-HCV antibodies (n=1479), HIV-1, 2 antigen/antibody (n=1489) and syphilis antibodies (n=1178). Furthermore, 498 vaginal and 410 cervical swab samples were tested for the presence of Streptococcus agalactiae as well as Mycoplasma hominis and Ureaplasma urealyticum, respectively. RESULTS: The seroprevalence of IgM and IgG antibodies was against TG 1.24% and 16.1%, RV 0.6% and 96.2%, CMV 5.44% and 77.7%, HSV-1 6.29% and 64.2%, HSV-2 2.4% and 6.7%. IgG avidity index was low for TG in 4 serum samples and in one sample for CMV. Positive IgM was confirmed with immunoblot in 4 HSV-2 cases. 0.24% serum samples were positive for HBsAg, 0.61% for anti-HCV positive and one sample for anti-syphilis total antibody. Herpes zoster was confirmed serologically in two patients. All samples were negative for HIV. Furthermore, 11.7% vaginal swab samples were positive for Streptococcus agalactiae, 1.5% cervical swab for Mycoplasma hominis and 10.2% for Ureaplasma urealyticum. CONCLUSIONS: We suggest that these analyses should be performed within the first trimester of pregnancy to confirm or to rule out primary infection. A high percentage of pregnant women seronegative for TG indicates the need for routine screening and education on prevention of infection. Vaccination should be advised to women of childbearing age who are seronegative to VZV.
TORCH syndrome; pregnancy; seroprevalence
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Podaci o prilogu
201-202.
2016.
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objavljeno
Podaci o matičnoj publikaciji
CROCMID 2016
Tambić Andrašević, Arjana ; Baršić, Bruno
Poreč: Hrvatski liječnički zbor ; Hrvatsko društvo za kliničku mikrobiologiju ; Hrvatsko društvo za infektivne bolesti
Podaci o skupu
11th CROATIAN CONGRESS OF CLINICAL MICROBIOLOGY 8th CROATIAN CONGRESS ON INFECTIOUS DISEASES with international participation
poster
20.10.2016-23.10.2016
Poreč, Hrvatska