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Pregled bibliografske jedinice broj: 846946

Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism


Snoj Tratnik, Janja; Falnoga, Ingrid; Trdin, Ajda; Mazej, Darja; Fajon, Vesna; Miklavčič, Ana; Kobal, Alfred; Osredkar, Joško; Sešek Briški, Alenka; Krsnik, Mladen et al.
Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism // Environmental research, 152 (2017), 375-385 doi:10.1016/j.envres.2016.08.035 (međunarodna recenzija, članak, znanstveni)


Naslov
Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism

Autori
Snoj Tratnik, Janja ; Falnoga, Ingrid ; Trdin, Ajda ; Mazej, Darja ; Fajon, Vesna ; Miklavčič, Ana ; Kobal, Alfred ; Osredkar, Joško ; Sešek Briški, Alenka ; Krsnik, Mladen ; Neubauer, David ; Kodrič, Jana ; Stropnik, Staša ; Gosar, David ; Lešnik Musek, Petra ; Marc, Janja ; Jurkovič Mlakar, Simona ; Petrović, Oleg ; Vlašić- Cicvarić, Inge ; Prpić, Igor ; Milardović, Ana ; Radić Nišević, Jelena ; Vuković, Danijela ; Fišić, Elizabeta ; Špirić, Zdravko ; Horvat, Milena

Izvornik
Environmental research (0013-9351) 152 (2017); 375-385

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mercury ; Selenium ; Lead ; Cord blood ; Neurodevelopment ; Apolipoprotein E ; Genetic polymorphism

Sažetak
The aim of the present study was to evaluate the association between prenatal exposure to mercury (Hg) and neurodevelopment of the child, taking into account genetic polymorphism of apolipoprotein E (Apoe) and other relevant confounders. Six hundred and one mother-child pairs were recruited from the central Slovenia region and 243 from Rijeka, on the Croatian coast of the northern Adriatic. The total Hg in cord blood, Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) assessment at 18 months of age and Apoe genotyping was performed on 361 children ; 237 of them were from Slovenia and 124 from Croatia. The results showed negative association between low- to-moderate Hg exposure in children with normal neurodevelopmental outcome and cognitive and fine motor scores at 18 months of age as assessed by BayleyIII. The Hg-related decrease in cognitive score was observed only in children carrying atleastone Apoe ε4 allele, while the decrease in fine motor scores was independent of the Apoe genotype. Adjusting for selenium (Se) and lead (Pb) levels, a positive association between Se and the language score and a negative association between Pb and the motor score was observed, but not in the subgroup of children carrying the ε4 allele.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kemijsko inženjerstvo, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
273-0222882-2698 - Bioindikacija onečišćenja zraka u terestričkim ekosustavima (Zdravko Špirić, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
OIKON d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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